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Silver fir (Abies alba L.) polyphenolic extract shows beneficial influence on chondrogenesis in vitro under normal and inflammatory conditions
ID Sirše, Mateja (Avtor), ID Fokter, Samo K. (Avtor), ID Štrukelj, Borut (Avtor), ID Zupan, Janja (Avtor)

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Izvleček
Several plant polyphenols have been shown to reduce osteoarthritis symptoms due to their antioxidant, anti-inflammatory and immunomodulatory properties. We investigated the effects of two different polyphenolic extracts (Belinal, Pycnogenol) and two different polyphenols (resveratrol, quercetin) on the chondrogenic potential of bone-derived mesenchymal stem/stromal cells (MSCs) from healthy donors and patients with osteoarthritis. Our main aim was to determine whether Belinal, a commercially available polyphenolic extract from silver fir (Abies alba L.) branches, has comparable chondrogenic potential with the other tested extract and the polyphenols under inflammatory and non-inflammatory conditions. In our study, Belinal promoted significantly greater chondrogenesis compared to the untreated (p = 0.0289) and resveratrol-treated (p = 0.0468) MSCs from patients with hip osteoarthritis under non-inflammatory conditions. Under inflammatory conditions, chondrogenesis was significantly enhanced for MSCs treated with Belinal compared to the control (p = 0.0483). The other extract and the polyphenols did not show any significant effects on chondrogenesis under non-inflammatory or inflammatory conditions. None of the tested extracts and polyphenols showed significant effects on chondrogenesis in healthy donors, under either non-inflammatory or inflammatory conditions. Our data show that Belinal can boost the chondrogenesis of MSCs derived from patients with osteoarthritis, under both non-inflammatory and inflammatory conditions.

Jezik:Angleški jezik
Ključne besede:mesenchymal stem cells, mesenchymal stromal cells, polyphenols, chondrogenesis, inflammation, subchondral bone, osteoarthritis
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2020
Št. strani:14 str.
Številčenje:Vol. 25, iss. 20, art. 4616
PID:20.500.12556/RUL-134462 Povezava se odpre v novem oknu
UDK:616.72-002
ISSN pri članku:1420-3049
DOI:10.3390/molecules25204616 Povezava se odpre v novem oknu
COBISS.SI-ID:32142339 Povezava se odpre v novem oknu
Datum objave v RUL:17.01.2022
Število ogledov:485
Število prenosov:175
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Molecules
Skrajšan naslov:Molecules
Založnik:MDPI
ISSN:1420-3049
COBISS.SI-ID:18462981 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:11.10.2020

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:polifenoli, stromalne celice, hondrogeneza, vnetje, osteoartritis, mezenhimske matične celice

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J3-1749
Naslov:Mezenhimske matične celice – nosilci endogene regenerativne sposobnosti tkiv v boju proti staranju mišično-skeletnega sistema

Financer:Drugi - Drug financer ali več financerjev
Program financ.:University Medical Centre Maribor
Številka projekta:IRP-2019/01-09

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