Silver fir (Abies alba L.) polyphenolic extract shows beneficial influence on chondrogenesis in vitro under normal and inflammatory conditions

Sirše, Mateja (avtor), Fokter, Samo K. (avtor), Štrukelj, Borut (avtor), Zupan, Janja (avtor)

Several plant polyphenols have been shown to reduce osteoarthritis symptoms due to their antioxidant, anti-inflammatory and immunomodulatory properties. We investigated the effects of two different polyphenolic extracts (Belinal, Pycnogenol) and two different polyphenols (resveratrol, quercetin) on the chondrogenic potential of bone-derived mesenchymal stem/stromal cells (MSCs) from healthy donors and patients with osteoarthritis. Our main aim was to determine whether Belinal, a commercially available polyphenolic extract from silver fir (Abies alba L.) branches, has comparable chondrogenic potential with the other tested extract and the polyphenols under inflammatory and non-inflammatory conditions. In our study, Belinal promoted significantly greater chondrogenesis compared to the untreated (p = 0.0289) and resveratrol-treated (p = 0.0468) MSCs from patients with hip osteoarthritis under non-inflammatory conditions. Under inflammatory conditions, chondrogenesis was significantly enhanced for MSCs treated with Belinal compared to the control (p = 0.0483). The other extract and the polyphenols did not show any significant effects on chondrogenesis under non-inflammatory or inflammatory conditions. None of the tested extracts and polyphenols showed significant effects on chondrogenesis in healthy donors, under either non-inflammatory or inflammatory conditions. Our data show that Belinal can boost the chondrogenesis of MSCs derived from patients with osteoarthritis, under both non-inflammatory and inflammatory conditions.

• Jezik: Angleški jezik
• Ključne besede: mesenchymal stem cells, mesenchymal stromal cells, polyphenols, chondrogenesis, inflammation, subchondral bone, osteoarthritis
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 14 str.
• Številčenje: Vol. 25, iss. 20, art. 4616
• PID: 20.500.12556/RUL-134462
• UDK: 616.72-002
• ISSN pri članku: 1420-3049
• DOI: 10.3390/molecules25204616
• COBISS.SI-ID: 32142339
• Datum objave v RUL: 17.01.2022

Gradivo je del revije

• Naslov: Molecules
• Skrajšan naslov: Molecules
• Založnik: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 11.10.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: polifenoli, stromalne celice, hondrogeneza, vnetje, osteoartritis, mezenhimske matične celice

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: J3-1749
• Naslov: Mezenhimske matične celice – nosilci endogene regenerativne sposobnosti tkiv v boju proti staranju mišično-skeletnega sistema

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: University Medical Centre Maribor
• Številka projekta: IRP-2019/01-09