Cysteine cathepsins : from diagnosis to targeted therapy of cancer

Ercegovič Rot, Ana (avtor), Hrovatin, Matija (avtor), Bokalj, Bor (avtor), Lavrih, Ernestina (avtor), Turk, Boris (avtor)

Cysteine cathepsins are a fascinating group of proteolytic enzymes that play diverse and crucial roles in numerous biological processes, both in health and disease. Understanding these proteases is essential for uncovering novel insights into the underlying mechanisms of a wide range of disorders, such as cancer. Cysteine cathepsins influence cancer biology by participating in processes such as extracellular matrix degradation, angiogenesis, immune evasion, and apoptosis. In this comprehensive review, we explore foundational research that illuminates the diverse and intricate roles of cysteine cathepsins as diagnostic markers and therapeutic targets for cancer. This review aims to provide valuable insights into the clinical relevance of cysteine cathepsins and explore their capacity to advance personalised and targeted medical interventions in oncology.

• Jezik: Angleški jezik
• Ključne besede: anticancer therapy, protease, cystein cathepsin, targeted drug delivery, cancer, diagnostic imaging
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: Str. 10-28
• Številčenje: Vol. 226
• PID: 20.500.12556/RUL-164866
• UDK: 577
• ISSN pri članku: 1638-6183
• DOI: 10.1016/j.biochi.2024.09.001
• COBISS.SI-ID: 214804227
• Datum objave v RUL: 14.11.2024

Gradivo je del revije

• Naslov: Biochimie
• Skrajšan naslov: Biochimie
• Založnik: Elsevier, Société Française de Biochimie et Biologie Moléculaire
• ISSN: 1638-6183
• COBISS.SI-ID: 193576195

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: onkološka terapija, protirakavo zdravljenje, proteaze, cisteinski katepsin, usmerjena dostava zdravil, katepsini, rak, onkologija, terapija z zdravili, diagnostično slikanje