Cysteine cathepsins : from diagnosis to targeted therapy of cancer

Ercegovič Rot, Ana (author), Hrovatin, Matija (author), Bokalj, Bor (author), Lavrih, Ernestina (author), Turk, Boris (author)

Cysteine cathepsins are a fascinating group of proteolytic enzymes that play diverse and crucial roles in numerous biological processes, both in health and disease. Understanding these proteases is essential for uncovering novel insights into the underlying mechanisms of a wide range of disorders, such as cancer. Cysteine cathepsins influence cancer biology by participating in processes such as extracellular matrix degradation, angiogenesis, immune evasion, and apoptosis. In this comprehensive review, we explore foundational research that illuminates the diverse and intricate roles of cysteine cathepsins as diagnostic markers and therapeutic targets for cancer. This review aims to provide valuable insights into the clinical relevance of cysteine cathepsins and explore their capacity to advance personalised and targeted medical interventions in oncology.

• Language: English
• Keywords: anticancer therapy, protease, cystein cathepsin, targeted drug delivery, cancer, diagnostic imaging
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: Str. 10-28
• Numbering: Vol. 226
• PID: 20.500.12556/RUL-164866
• UDC: 577
• ISSN on article: 1638-6183
• DOI: 10.1016/j.biochi.2024.09.001
• COBISS.SI-ID: 214804227
• Publication date in RUL: 14.11.2024

Record is a part of a journal

• Title: Biochimie
• Shortened title: Biochimie
• Publisher: Elsevier, Société Française de Biochimie et Biologie Moléculaire
• ISSN: 1638-6183
• COBISS.SI-ID: 193576195

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: onkološka terapija, protirakavo zdravljenje, proteaze, cisteinski katepsin, usmerjena dostava zdravil, katepsini, rak, onkologija, terapija z zdravili, diagnostično slikanje