Cardiovascular drugs as water contaminants and analytical challenges in the evaluation of their degradation

Kravos, Aleksander (avtor), Žgajnar Gotvajn, Andreja (avtor), Prosen, Helena (avtor)

Cardiovascular drugs have been a burning topic in the field of environmental analytical chemistry in the last few decades. Growing modern healthcare has led to the widespread use of pharmaceuticals. Among these, antihypertensives (sartans, angiotensin-converting enzyme inhibitors) and lipid-regulating drugs (fibrates and statins) are the most frequently consumed and, thus, excreted into wastewater. Their chemical fate during conventional and advanced wastewater treatment, such as ozonation, remains unclear. Analytical chemistry, providing sample pretreatment followed by instrumental analysis, has a tremendous role in water treatment evaluation, mostly from the perspective of parent contaminants’ removals and also assessment of transformation pathways. Ultrasensitive liquid chromatography–mass spectrometry (LC-MS) systems provide many opportunities. By carefully using planned workflows for chromatographic and mass-spectrometric data processing, i.e., suspect and non-target screening approaches, LC-MS allows for the identification and structural elucidation of unknown, predicted, suspected or selected transformation products. Accordingly, some examples and case studies on selected cardiovascular drugs in this review are presented to show the applicability of the used analytical approaches and workflows.

• Jezik: Angleški jezik
• Ključne besede: LC-MS, ozonation, pharmaceuticals, structural elucidation, transformation products, wastewater
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 30 str.
• Številčenje: Vol. 12, iss. 10, art. 2177
• PID: 20.500.12556/RUL-163511
• UDK: 628.349:66.094.3-926.214:615.22:543.544.5
• ISSN pri članku: 2227-9717
• DOI: 10.3390/pr12102177
• COBISS.SI-ID: 210592771
• Datum objave v RUL: 08.10.2024

Gradivo je del revije

• Naslov: Processes
• Skrajšan naslov: Processes
• Založnik: MDPI
• ISSN: 2227-9717
• COBISS.SI-ID: 523353113

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: LC-MS, ozonacija, zdravila, strukturna identifikacija, transformacijski produkti, odpadne vode