20.500.12556/RUL-163511 Cardiovascular drugs as water contaminants and analytical challenges in the evaluation of their degradation Cardiovascular drugs have been a burning topic in the field of environmental analytical chemistry in the last few decades. Growing modern healthcare has led to the widespread use of pharmaceuticals. Among these, antihypertensives (sartans, angiotensin-converting enzyme inhibitors) and lipid-regulating drugs (fibrates and statins) are the most frequently consumed and, thus, excreted into wastewater. Their chemical fate during conventional and advanced wastewater treatment, such as ozonation, remains unclear. Analytical chemistry, providing sample pretreatment followed by instrumental analysis, has a tremendous role in water treatment evaluation, mostly from the perspective of parent contaminants’ removals and also assessment of transformation pathways. Ultrasensitive liquid chromatography–mass spectrometry (LC-MS) systems provide many opportunities. By carefully using planned workflows for chromatographic and mass-spectrometric data processing, i.e., suspect and non-target screening approaches, LC-MS allows for the identification and structural elucidation of unknown, predicted, suspected or selected transformation products. Accordingly, some examples and case studies on selected cardiovascular drugs in this review are presented to show the applicability of the used analytical approaches and workflows. LC-MS ozonation pharmaceuticals structural elucidation transformation products wastewater LC-MS ozonacija zdravila strukturna identifikacija transformacijski produkti odpadne vode true false true Angleški jezik Slovenski jezik Članek v reviji 2024-10-08 10:13:54 2024-10-08 10:13:55 2024-10-10 03:41:22 0000-00-00 00:00:00 2024 0 0 30 str. iss. 10, art. 2177 Vol. 12 Oct. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 628.349:66.094.3-926.214:615.22:543.544.5 2227-9717 10.3390/pr12102177 210592771 processes-12-02177.pdf processes-12-02177.pdf 1 36E80C6175DA22BEA657E8C076FE674F a019ad1fa6e4293d3c51bdcbe8c1e8a563126bc96da97bac0afaea1a19ada516 a9f6db70-854d-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=193254 https://www.mdpi.com/2227-9717/12/10/2177 1 1670c89a-854d-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=193253 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0