izpis_h1_title_alt

Basic exploratory study of bisphenol A (BPA) dietary administration to Istrian Pramenka rams and male toxicity investigation
ID Šturm, Sabina (Avtor), ID Weber, Klaus (Avtor), ID Klinc, Primož (Avtor), ID Spörndly-Nees, Ellinoir (Avtor), ID Fakhrzadeh, Azadeh (Avtor), ID Knific, Tanja (Avtor), ID Škibin, Andrej (Avtor), ID Fialová, Věra (Avtor), ID Okazaki, Yoshimasa (Avtor), ID Razinger, Tanja (Avtor), ID Laufs, Jürgen (Avtor), ID Kreutzer, Robert (Avtor), ID Pogačnik, Milan (Avtor), ID Švara, Tanja (Avtor), ID Cerkvenik, Vesna (Avtor)

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Izvleček
Bisphenol A (BPA), an endocrine-disrupting chemical and environmental pollutant, has been reported by many researchers to induce male reproductive toxicity in different experimental models. In this study, we investigated whether long-term exposure for two months to 25 ug/kg body weight (low dose) of BPA affects spermatogenesis or sperm quality in young Istrian Pramenka rams exposed via diet. We evaluated body and testicular weights, histopathology of testes and epididymides, and sperm analyses, and compared these parameters between the group of treated rams and the control group of rams. Although there were some differences between the two groups, these differences were not large or statistically significant. The only statistically significant difference was the lower epithelial height of seminiferous tubules in treated rams, compared to control rams. In addition to assessing toxicity, BPA concentrations in the blood plasma of treated rams were determined after the first administration, and the toxicokinetic parameters of total BPA were calculated. In this study, no major signs of altered reproduction in rams were detected.

Jezik:Angleški jezik
Ključne besede:bisphenol A, rams, toxicokinetics, male toxicity, sperm
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
Leto izida:2022
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:17 str.
Številčenje:Vol. 10, no. 5, art. 224
PID:20.500.12556/RUL-136542 Povezava se odpre v novem oknu
UDK:636.09:615.9
ISSN pri članku:2305-6304
DOI:10.3390/toxics10050224 Povezava se odpre v novem oknu
COBISS.SI-ID:107203843 Povezava se odpre v novem oknu
Datum objave v RUL:10.05.2022
Število ogledov:76
Število prenosov:37
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Toxics
Skrajšan naslov:Toxics
Založnik:MDPI
ISSN:2305-6304
COBISS.SI-ID:520262681 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:10.05.2022

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P4-0092
Naslov:Zdravje živali, okolje in varna hrana

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Program financ.:Postgraduate (Ph.D.) research funding

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