20.500.12556/RUL-136542
Basic exploratory study of bisphenol A (BPA) dietary administration to Istrian Pramenka rams and male toxicity investigation
Bisphenol A (BPA), an endocrine-disrupting chemical and environmental pollutant, has
been reported by many researchers to induce male reproductive toxicity in different experimental
models. In this study, we investigated whether long-term exposure for two months to 25 ug/kg
body weight (low dose) of BPA affects spermatogenesis or sperm quality in young Istrian Pramenka
rams exposed via diet. We evaluated body and testicular weights, histopathology of testes and
epididymides, and sperm analyses, and compared these parameters between the group of treated
rams and the control group of rams. Although there were some differences between the two groups,
these differences were not large or statistically significant. The only statistically significant difference
was the lower epithelial height of seminiferous tubules in treated rams, compared to control rams. In
addition to assessing toxicity, BPA concentrations in the blood plasma of treated rams were determined
after the first administration, and the toxicokinetic parameters of total BPA were calculated. In
this study, no major signs of altered reproduction in rams were detected.
bisphenol A
rams
toxicokinetics
male toxicity
sperm
true
false
true
Angleški jezik
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2022-05-10 12:36:37
2022-05-10 12:36:42
2022-09-15 04:13:58
0000-00-00 00:00:00
2022
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17 str.
no. 5, art. 224
Vol. 10
2022
0000-00-00
Zaloznikova
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0000-00-00
0000-00-00
0000-00-00
636.09:615.9
2305-6304
10.3390/toxics10050224
107203843
Basic-Sturm.pdf
Basic-Sturm.pdf
1
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d6ea0789aaee8ffdcfd3ad97fb45b70c788d570428b6dd9fcd155cd48eb05a18
a33108b6-d04d-11ec-8aca-00155dcfd717
https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156235
https://www.mdpi.com/2305-6304/10/5/224
1
fb7709ca-d04c-11ec-8aca-00155dcfd717
https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156233
Veterinarska fakulteta
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