Basic exploratory study of bisphenol A (BPA) dietary administration to Istrian Pramenka rams and male toxicity investigation

Šturm, Sabina (author), Weber, Klaus (author), Klinc, Primož (author), Spörndly-Nees, Ellinoir (author), Fakhrzadeh, Azadeh (author), Knific, Tanja (author), Škibin, Andrej (author), Fialová, Věra (author), Okazaki, Yoshimasa (author), Razinger, Tanja (author), Laufs, Jürgen (author), Kreutzer, Robert (author), Pogačnik, Milan (author), Švara, Tanja (author), Cerkvenik, Vesna (author)

Bisphenol A (BPA), an endocrine-disrupting chemical and environmental pollutant, has been reported by many researchers to induce male reproductive toxicity in different experimental models. In this study, we investigated whether long-term exposure for two months to 25 ug/kg body weight (low dose) of BPA affects spermatogenesis or sperm quality in young Istrian Pramenka rams exposed via diet. We evaluated body and testicular weights, histopathology of testes and epididymides, and sperm analyses, and compared these parameters between the group of treated rams and the control group of rams. Although there were some differences between the two groups, these differences were not large or statistically significant. The only statistically significant difference was the lower epithelial height of seminiferous tubules in treated rams, compared to control rams. In addition to assessing toxicity, BPA concentrations in the blood plasma of treated rams were determined after the first administration, and the toxicokinetic parameters of total BPA were calculated. In this study, no major signs of altered reproduction in rams were detected.

• Language: English
• Keywords: bisphenol A, rams, toxicokinetics, male toxicity, sperm
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: VF - Veterinary Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 17 str.
• Numbering: Vol. 10, no. 5, art. 224
• PID: 20.500.12556/RUL-136542
• UDC: 636.09:615.9
• ISSN on article: 2305-6304
• DOI: 10.3390/toxics10050224
• COBISS.SI-ID: 107203843
• Publication date in RUL: 10.05.2022

Record is a part of a journal

• Title: Toxics
• Shortened title: Toxics
• Publisher: MDPI
• ISSN: 2305-6304
• COBISS.SI-ID: 520262681

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 10.05.2022

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P4-0092
• Name: Zdravje živali, okolje in varna hrana

• Funder: ARRS - Slovenian Research Agency
• Funding programme: Postgraduate (Ph.D.) research funding