Solubility of luteolin and other polyphenolic compounds in water, nonpolar, polar aprotic and protic solvents by applying FTIR/HPLC

Rajhard, Saša (avtor), Hladnik, Lucija (avtor), Vicente, Filipa A. (avtor), Srčič, Stanko (avtor), Grilc, Miha (avtor), Likozar, Blaž (avtor)

In recent years, flavonoids have become a highly researched topic due to their health beneficial effects. Since flavonoids’ solubility plays a significant role in their use in pharmaceutical, food, biological, and chemical areas, the determination of suitable solvents is crucial. Fourier transform infrared (FTIR) analysis was used to characterize functional groups of several flavonoids and phenolic compounds, namely luteolin, hesperidin, quercetin, naringenin, gallic acid and tannic acid. Concentration dependence on transmittance was evaluated for these compounds in ethanol. Afterwards, luteolin was chosen as a model flavonoid, with its concentration correlated with transmittance using 15 solvents with different polarities. Luteolin solubility was further corroborated with high-performance liquid chromatography (HPLC). These results shed light on using FTIR as a semi-quantitative method for the initial screening of solvents and the solubility of different compounds while saving time and solvents. Hence, HPLC would only be needed as a final step for the most promising solvents.

• Jezik: Angleški jezik
• Ključne besede: luteolin, dissolution, fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy, fast quantification tool, high-performance liquid chromatography (HPLC)
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 15 str.
• Številčenje: Vol. 9, iss. 11, art. 1952
• PID: 20.500.12556/RUL-136428
• UDK: 577
• ISSN pri članku: 2227-9717
• DOI: 10.3390/pr9111952
• COBISS.SI-ID: 85080835
• Datum objave v RUL: 03.05.2022

Gradivo je del revije

• Naslov: Processes
• Skrajšan naslov: Processes
• Založnik: MDPI
• ISSN: 2227-9717
• COBISS.SI-ID: 523353113

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.11.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: biokemija, FTIR, flavonoidi, Fourierjeva transformacija