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Sex-related differences in cardiovascular disease risk profile in children and adolescents with type 1 diabetes
ID Šmigoc Schweiger, Darja (Avtor), ID Battelino, Tadej (Avtor), ID Grošelj, Urh (Avtor)

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Izvleček
Cardiovascular disease (CVD) is the primary cause of higher and earlier morbidity and mortality in people with type 1 diabetes (T1D) compared to people without diabetes. In addition, women with T1D are at an even higher relative risk for CVD than men. However, the underlying pathophysiology is not well understood. Atherosclerotic changes are known to progress early in life among people with T1D, yet it is less clear when excess CVD risk begins in females with T1D. This review explores the prevalence of classical CVD risk factors (such as glycemic control, hypertension, dyslipidemia, obesity, albuminuria, smoking, diet, physical inactivity), as well as of novel biomarkers (such as chronic inflammation), in children and adolescents with T1D with particular regard to sex-related differences in risk profile. We also summarize gaps where further research and clearer clinical guidance are needed to better address this issue. Considering that girls with T1D might have a more adverse CVD risk profile than boys, the early identification of and sex-specific intervention in T1D would have the potential to reduce later CVD morbidity and excess mortality in females with T1D. To conclude, based on an extensive review of the existing literature, we found a clear difference between boys and girls with T1D in the presence of individual CVD risk factors as well as in overall CVD risk profiles; the girls were on the whole more impacted.

Jezik:Angleški jezik
Ključne besede:sex, gender, cardiovascular risk factors, type 1 diabetes, children, adolescents, blood pressure, hyperglycemia, dyslipidemia, inflammation, smoking
Vrsta gradiva:Članek v reviji
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2021
Št. strani:29 str.
Številčenje:Vol. 22, iss. 19, art. 10192
PID:20.500.12556/RUL-136338 Povezava se odpre v novem oknu
UDK:616.379
ISSN pri članku:1422-0067
DOI:10.3390/ijms221910192 Povezava se odpre v novem oknu
COBISS.SI-ID:77665795 Povezava se odpre v novem oknu
Datum objave v RUL:25.04.2022
Število ogledov:683
Število prenosov:86
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:International journal of molecular sciences
Skrajšan naslov:Int. j. mol. sci.
Založnik:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:01.10.2021

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:spol, tveganje za srčno-žilna obolenja, sladkorna bolezen tipa 1, otroci, mladostniki, krvni tlak, hiperglikemija, dislipidemija, kajenje, infekcijske bolezni

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0343
Naslov:Etiologija, zgodnje odkrivanje in zdravljenje bolezni pri otrocih in mladostnikih

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J3-2536
Naslov:Ugotavljanje genetskih vzrokov dislipidemij pri otrocih in mladostnikih ter njihovo zgodnje odkrivanje s populacijskim presejanjem

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