20.500.12556/RUL-136338 Sex-related differences in cardiovascular disease risk profile in children and adolescents with type 1 diabetes Cardiovascular disease (CVD) is the primary cause of higher and earlier morbidity and mortality in people with type 1 diabetes (T1D) compared to people without diabetes. In addition, women with T1D are at an even higher relative risk for CVD than men. However, the underlying pathophysiology is not well understood. Atherosclerotic changes are known to progress early in life among people with T1D, yet it is less clear when excess CVD risk begins in females with T1D. This review explores the prevalence of classical CVD risk factors (such as glycemic control, hypertension, dyslipidemia, obesity, albuminuria, smoking, diet, physical inactivity), as well as of novel biomarkers (such as chronic inflammation), in children and adolescents with T1D with particular regard to sex-related differences in risk profile. We also summarize gaps where further research and clearer clinical guidance are needed to better address this issue. Considering that girls with T1D might have a more adverse CVD risk profile than boys, the early identification of and sex-specific intervention in T1D would have the potential to reduce later CVD morbidity and excess mortality in females with T1D. To conclude, based on an extensive review of the existing literature, we found a clear difference between boys and girls with T1D in the presence of individual CVD risk factors as well as in overall CVD risk profiles; the girls were on the whole more impacted. sex gender cardiovascular risk factors type 1 diabetes children adolescents blood pressure hyperglycemia dyslipidemia inflammation smoking spol tveganje za srčno-žilna obolenja sladkorna bolezen tipa 1 otroci mladostniki krvni tlak hiperglikemija dislipidemija kajenje infekcijske bolezni true false true Angleški jezik Slovenski jezik Članek v reviji 2022-04-25 11:13:06 2022-04-25 11:13:07 2022-09-15 04:13:46 0000-00-00 00:00:00 2021 0 0 29 str. iss. 19, art. 10192 Vol. 22 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.379 1422-0067 10.3390/ijms221910192 77665795 ijms-22-10192-v2.pdf ijms-22-10192-v2.pdf 1 F5BE1235D97CA15BF66AF8FF15397BEB 85a3cf7f1dd8808adfbc20931ecb880a5fc106712b4cd7281b77662870ffefcd 1b192af5-c478-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155925 https://www.mdpi.com/1422-0067/22/19/10192 1 d84ace5d-c477-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155924 Medicinska fakulteta 0 0 0