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Nitrosative stress in the frontal cortex from dogs with canine cognitive dysfunction
Prpar Mihevc, Sonja (Avtor), Zakošek, Maja (Avtor), Štrbenc, Malan (Avtor), Rogelj, Boris (Avtor), Majdič, Gregor (Avtor)

URLURL - Izvorni URL, za dostop obiščite https://www.frontiersin.org/articles/10.3389/fvets.2020.573155/full Povezava se odpre v novem oknu

Izvleček
Canine cognitive dysfunction (CCD) is an age-related disorder similar to human Alzheimer's disease (AD) that occurs in elderly dogs. Nitrosative stress has been implicated as one of the causes leading to neurodegenerative diseases, particularly AD. Its involvement in the development of CCD has not been studied so far. In the present study, immunohistochemical staining detected all three isoforms of nitric oxide synthases (nNOS, eNOS, and iNOS) and 3-nitrotyrosine (3-NT) in brains from CCD-affected dogs and non-demented control dogs in all layers of the canine frontal cortex. In CCD-affected and non-demented brains, nNOS was highly expressed in pyramidal-like neurons in the upper cortical layers. nNOS has also been observed in astrocytes in the CCD frontal cortex. The nNOS immunohistochemical staining was statistically significantly elevated in dogs with CCD in comparison to non-demented dogs. Blood vessel wall cells were positive for eNOS, which was also expressed in astrocytes and neurons. Intense 3-NT immunoreactivity was observed in the upper cortical layers, where amyloid-beta deposits spread in the last stage of CCD. Brain cells in the same area were highly immunoreactive for iNOS. This infers that neuroinflammation and nitrosative stress might exacerbate the neurodegenerative process in CCD-affected brains, ultimately leading to cognitive impairment

Jezik:Angleški jezik
Ključne besede:Canine cognitive dysfunction, nitrosative stress, nNOS, eNOS, iNOS, 3-nitrotyrosine
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
Leto izida:2020
Št. strani:art. 573155, str. 1-14
Številčenje:Vol. 7
UDK:636.7.09:616.89
ISSN pri članku:2297-1769
DOI:10.3389/fvets.2020.573155 Povezava se odpre v novem oknu
COBISS.SI-ID:38304259 Povezava se odpre v novem oknu
Število ogledov:217
Število prenosov:63
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Frontiers in veterinary science
Skrajšan naslov:Front. vet. sci.
Založnik:Frontiers Media
ISSN:2297-1769
COBISS.SI-ID:3969402 Povezava se odpre v novem oknu

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Program financ.:Evropski sklad za regionalni razvoj, Raziskovalci na začetku kariere 2.0
Številka projekta:P4-0053
Naslov:Razvoj in uporaba naprednih celičnih terapij za zdravljenje demence pri psih
Akronim:C3330-17-529031

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:19.11.2020

Sekundarni jezik

Jezik:Ni določen
Ključne besede:Pasja kognitivna motnja, nitrozativni stres, nNOS, eNOS, iNOS, 3-nitrotirozin

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