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PhD theses (2)
Žiga Skok:
Načrtovanje, sinteza in vrednotenje novih ATP-kompetitivnih zaviralcev človeške DNA-topoizomeraze II kot potencialnih protirakavih učinkovin
Nina Žigart:
Kombiniran pristop k študiju kemizma razgradnje venetoklaksa z in silico orodji in načrtovanimi stresnimi testi
MSc theses (10)
Tamara Kolar:
In vitro določanje aktivnosti potencialnih antitrombotičnih učinkovin morskega izvora
Jure Požar:
Sinteza potencialnih zaviralcev giraze B z 1,4-benzoksazinskim skeletom
Lucija Drobnič:
Določanje stabilnosti spojin iz knjižnice zaviralcev trombina s tekočinsko kromatografijo visoke ločljivosti
Jernej Hafner:
Analiza termodinamskih parametrov vezave zaviralcev tripsina z izotermno titracijsko kalorimetrijo
Klara Kunc:
Iskanje novih zaviralcev histonske deacetilaze z virtualnim rešetanjem
Jernej Marko Lobe:
Design and synthesis of novel lysine-specific demethylase 1 inhibitors
Polona Lužar:
Določevanje izpostavljenosti ksilenom v histološkem in citološkem laboratoriju
Jasmina Jeznik:
Validacija metod za določanje vode in vodne aktivnosti v vitaminskih tabletah
Anja Mestnik:
Identification of compounds in honey of French origin and their potential antimcrobial properties
Jure Požar:
Sinteza potencialnih zaviralcev giraze B z 1,4-benzoksazinskim skeletom
BSc theses (5)
Davor Štirn:
Priprava enantiomerno čistih antitrombotičnih spojin z uporabo kiralne tekočinske kromatografije visoke ločljivosti
Aleksander Miložič:
Uporaba Wittigove reakcije pri sintezi novih dualnih antitrombotičnih učinkovin
Uroš Trstenjak:
Načrtovanje in sinteza gradnikov novih inhibitorjev faktorja Xa
Saša Ciglič:
Sinteza derivatov benzo[b][1,4]dioksina in benzo[b][1,4]oksazina kot gradnikov dualnih antitrombotičnih učinkovin
Vika Kobola:
Sinteza analogov spumiginov kot potencialnih antitrombotičnih učinkovin
Other documents (29)
Steve Peigneur, Aleš Žula, Nace Zidar, Fiona Chan-Porter, Robert Kirby, David J. Madge, Janez Ilaš, Danijel Kikelj, Jan Tytgat:
Action of clathrodin and analogues on voltage-gated sodium channels
Nace Zidar, Sofia Montalvão, Žiga Hodnik, Dorota A. Nawrot, Aleš Žula, Janez Ilaš, Danijel Kikelj, Päivi Tammela, Lucija Peterlin-Mašič:
Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues
Tihomir Tomašič, Matic Mirt, Michaela Barančokova, Janez Ilaš, Nace Zidar, Päivi Tammela, Danijel Kikelj:
Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors
Žiga Jakopin, Janez Ilaš, Michaela Barančokova, Matjaž Brvar, Päivi Tammela, Marija Sollner Dolenc, Tihomir Tomašič, Danijel Kikelj:
Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors
Martina Durcik, Päivi Tammela, Michaela Barančokova, Tihomir Tomašič, Janez Ilaš, Danijel Kikelj, Nace Zidar:
Synthesis and evaluation of N-phenylpyrrolamides as DNA gyrase B inhibitors
Martina Durcik, Andrej Emanuel Cotman, Žan Toplak, Štefan Možina, Žiga Skok, Maria Vittoria Piras, Nace Zidar, Janez Ilaš, Anamarija Zega, Jurij Trontelj, Danijel Kikelj, Tihomir Tomašič, Lucija Peterlin-Mašič:
New dual inhibitors of bacterial topoisomerases with broad-spectrum antibacterial activity and in vivo efficacy against vancomycin-intermediate Staphylococcus aureus
Špela Gubič, Janez Ilaš, Tihomir Tomašič, Annarosa Arcangeli, Lucija Peterlin-Mašič:
Immunosuppressive effects of new thiophene-based K$_V$1.3 inhibitors
Žiga Skok, Martina Durcik, Živa Zajec, Darja Gramec, Krištof Bozovičar, Anja Pišlar, Tihomir Tomašič, Anamarija Zega, Lucija Peterlin-Mašič, Danijel Kikelj, Nace Zidar, Janez Ilaš:
ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold
Nace Zidar, Alessia Onali, Peter Peršolja, Davide Benedetto Tiz, Jaka Dernovšek, Žiga Skok, Martina Durcik, Andrej Emanuel Cotman, Martina Hrast, Anamarija Zega, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašič, Danijel Kikelj:
Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains
Petra Dunkel, Janez Ilaš:
Targeted cancer therapy using compounds activated by light
Michaela Barančokova, Danijel Kikelj, Janez Ilaš:
Recent progress in the discovery and development of DNA gyrase B inhibitors
Aleš Žula, Izabela Będziak, Danijel Kikelj, Janez Ilaš:
Synthesis and evaluation of spumigin analogues library with thrombin inhibitory activity
Polya G. Roydeva, Anna-Madeleine Beckmann, Marit Stirnberg, Jožko Cesar, Danijel Kikelj, Janez Ilaš, Michael Gütschow:
3,1-Benzothiazines, 1,4-benzodioxines, 1,4-benzoxazines as inhibitors of matriptase-2
Nina Žigart, Martin Črnugelj, Janez Ilaš, Zdenko Časar:
On the stability and degradation pathways of venetoclax under stress conditions
Tihomir Tomašič, Asta Zubrienė, Žiga Skok, Riccardo Martini, Stane Pajk, Izidor Sosič, Janez Ilaš, Daumantas Matulis, Sharon D. Bryant:
Selective DNA gyrase inhibitors
Martina Durcik, Žiga Skok, Janez Ilaš, Nace Zidar, Anamarija Zega, Petra Szili, Gábor Draskovits, T. Revesz, Danijel Kikelj, Ákos Nyerges, Csaba Pál, Lucija Peterlin-Mašič, Tihomir Tomašič:
Hybrid inhibitors of DNA gyrase A and B
Marina Gjorgjieva, Tihomir Tomašič, Michaela Barančokova, Sotirios Katsamakas, Janez Ilaš, Päivi Tammela, Lucija Peterlin-Mašič, Danijel Kikelj:
Discovery of benzothiazole scaffold-based DNA gyrase B inhibitors
Žiga Skok, Michaela Barančokova, Ondřej Benek, Cristina Durante Cruz, Päivi Tammela, Tihomir Tomašič, Nace Zidar, Lucija Peterlin-Mašič, Anamarija Zega, Danijel Kikelj, Janez Ilaš:
Exploring the chemical space of benzothiazole-based DNA gyrase B inhibitors
Martina Durcik, Žan Toplak, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lucija Peterlin-Mašič, Tihomir Tomašič:
Efficient synthesis of hydroxy-substituted 2-aminobenzo[d]thiazole-6-carboxylic acid derivatives as new building blocks in drug discovery
Ákos Nyerges, Tihomir Tomašič, Martina Durcik, T. Revesz, Petra Szili, Žiga Skok, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lucija Peterlin-Mašič:
Rational design of balanced dual-targeting antibiotics with limited resistance
Péter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György Keserü M.:
Next-generation heterocyclic electrophiles as small-molecule covalent MurA inhibitors
Andrej Emanuel Cotman, Martina Durcik, Davide Benedetto Tiz, Federica Fulgheri, Daniela Secci, Maša Sterle, Štefan Možina, Žiga Skok, Nace Zidar, Anamarija Zega, Janez Ilaš, Lucija Peterlin-Mašič, Tihomir Tomašič, Danijel Kikelj:
Discovery and hit-to-lead optimization of benzothiazole scaffold-based DNA gyrase inhibitors with potent activity against Acinetobacter baumannii and Pseudomonas aeruginosa
Maša Sterle, Martina Durcik, Danijel Kikelj, Nace Zidar, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašič, Andrej Emanuel Cotman, Anamarija Zega:
Exploring the 5-substituted 2-aminobenzothiazole-based DNA gyrase B inhibitors active against ESKAPE pathogens
Ana Jug, Tomaž Bratkovič, Janez Ilaš:
Biolayer interferometry and its applications in drug discovery and development
Nace Zidar, Andrej Emanuel Cotman, Wessel Sinnige, Ondřej Benek, Michaela Barančokova, Anamarija Zega, Lucija Peterlin-Mašič, Tihomir Tomašič, Janez Ilaš, Ricardo D. Enriz, Danijel Kikelj:
Exploring the interaction of N-(benzothiazol-2-yl)pyrrolamide DNA gyrase inhibitors with the GyrB ATP-binding site lipophilic floor
Martina Piga, Zoltán Varga, Ádám Fehér, Ferenc Papp, Eva Korpos Pintye-Gyuri, Kavya C. Bangera, Rok Frlan, Janez Ilaš, Jaka Dernovšek, Tihomir Tomašič, Nace Zidar:
Identification of a novel structural class of H$_v$1 inhibitors by structure-based virtual screening
Andrej Emanuel Cotman, Federica Fulgheri, Martina Piga, Peter Peršolja, Davide Benedetto Tiz, Žiga Skok, Martina Durcik, Maša Sterle, Jaka Dernovšek, Anamarija Zega, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašič, Danijel Kikelj, Nace Zidar:
New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity
Jaka Dernovšek, Živa Zajec, Dunja Urbančič, Ana Jug, Žiga Skok, Janez Ilaš, Nace Zidar, Tihomir Tomašič:
Hiding in plain sight
Jaka Dernovšek, Dunja Urbančič, Živa Zajec, Žiga Skok, Janez Ilaš, Nace Zidar, Tihomir Tomašič:
First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo