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Targeted cancer therapy using compounds activated by light
ID
Dunkel, Petra
(
Author
),
ID
Ilaš, Janez
(
Author
)
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MD5: 967751BFADC5058F09C21DB25893AA45
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https://www.mdpi.com/2072-6694/13/13/3237
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Abstract
Cancer chemotherapy is affected by a modest selectivity and toxic side effects of pharmacological interventions. Among novel approaches to overcome this limitation and to bring to therapy more potent and selective agents is the use of light for selective activation of anticancer compounds. In this review, we focus on the anticancer applications of two light-activated approaches still in the experimental phase: photoremovable protecting groups (''photocages'') and photoswitches. We describe the structural considerations behind the development of novel compounds and the plethora of assays used to confirm whether the photochemical and pharmacological properties are meeting the stringent criteria for an efficient in vivo light-dependent activation. Despite its immense potential, light activation brings many challenges, and the complexity of the task is very demanding. Currently, we are still deeply in the phase of pharmacological tools, but the vivid research and rapid development bring the light of hope for potential clinical use.
Language:
English
Keywords:
photocages
,
photoswitches
,
photopharmacology
,
light-activatable materials
,
photoresponsive drug delivery systems
,
azobenzenes
Work type:
Article
Typology:
1.02 - Review Article
Organization:
FFA - Faculty of Pharmacy
Publication status:
Published
Publication version:
Version of Record
Year:
2021
Number of pages:
49 str.
Numbering:
Vol. 13, iss. 13, art. 3237
PID:
20.500.12556/RUL-135435
UDC:
615.015.14
ISSN on article:
2072-6694
DOI:
10.3390/cancers13133237
COBISS.SI-ID:
69036803
Publication date in RUL:
15.03.2022
Views:
679
Downloads:
115
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Record is a part of a journal
Title:
Cancers
Shortened title:
Cancers
Publisher:
MDPI
ISSN:
2072-6694
COBISS.SI-ID:
517914137
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
01.07.2021
Secondary language
Language:
Slovenian
Keywords:
azobenzeni
,
fotostikala
,
svetlobno aktivirani materiali
,
fotoodzivni dostavni sistemi
,
fotofarmakologija
,
dostavni sistemi
,
fotokemijske reakcije
,
rak
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0208
Name:
Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin
Funder:
ARRS - Slovenian Research Agency
Project number:
N1-0172
Name:
Fotokemijski pristop za odkrivanje naprednih ATP-kompetitivnih prob z zaviralnim delovanjem na topoizomerazo II alfa
Funder:
Other - Other funder or multiple funders
Funding programme:
National Research, Development and Innovation Office (NKFIH)
Project number:
P1-020
Funder:
Other - Other funder or multiple funders
Funding programme:
National Research, Development and Innovation Office (NKFIH)
Project number:
SNN 135825
Funder:
Other - Other funder or multiple funders
Funding programme:
Ministry of Innovation and Technology, New National Excellence Program
Project number:
ÚNKP-20-5
Funder:
Other - Other funder or multiple funders
Funding programme:
Hungarian Academy of Sciences, János Bolyai Research Scholarship
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