20.500.12556/RUL-135435 Targeted cancer therapy using compounds activated by light Cancer chemotherapy is affected by a modest selectivity and toxic side effects of pharmacological interventions. Among novel approaches to overcome this limitation and to bring to therapy more potent and selective agents is the use of light for selective activation of anticancer compounds. In this review, we focus on the anticancer applications of two light-activated approaches still in the experimental phase: photoremovable protecting groups (''photocages'') and photoswitches. We describe the structural considerations behind the development of novel compounds and the plethora of assays used to confirm whether the photochemical and pharmacological properties are meeting the stringent criteria for an efficient in vivo light-dependent activation. Despite its immense potential, light activation brings many challenges, and the complexity of the task is very demanding. Currently, we are still deeply in the phase of pharmacological tools, but the vivid research and rapid development bring the light of hope for potential clinical use. photocages photoswitches photopharmacology light-activatable materials photoresponsive drug delivery systems azobenzenes azobenzeni fotostikala svetlobno aktivirani materiali fotoodzivni dostavni sistemi fotofarmakologija dostavni sistemi fotokemijske reakcije rak true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-15 08:03:46 2022-03-15 08:03:50 2022-09-14 04:13:18 0000-00-00 00:00:00 2021 0 0 49 str. iss. 13, art. 3237 Vol. 13 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.015.14 2072-6694 10.3390/cancers13133237 69036803 RAZ_Dunkel_Petra_2021.pdf RAZ_Dunkel_Petra_2021.pdf 1 967751BFADC5058F09C21DB25893AA45 a837b9f606882e0fee90aa2af490b559c47452ec6a228a3a835c111a579810e9 6e7316e6-a42e-11ec-8556-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154508 https://www.mdpi.com/2072-6694/13/13/3237 1 104daf94-a42e-11ec-8556-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154507 Fakulteta za farmacijo 0 0 0