How to tackle therapeutic inertia in heart failure with reduced ejection fraction : a scientific statement of the Heart Failure Association of the ESC

Savarese, Gianluigi (avtor), Lindberg, Felix (avtor), Cannata, Antonio (avtor), Chioncel, Ovidiu (avtor), Stolfo, Davide (avtor), Musella, Francesca (avtor), Tomasoni, Daniela (avtor), Abdelhamid, Magdy (avtor), Banerjee, Debasish (avtor), Bayes-Genis, Antoni (avtor), Lainščak, Mitja (avtor)

Guideline-directed medical therapy (GDMT) in patients with heart failure and reduced ejection fraction (HFrEF) reduces morbidity and mortality, but its implementation is often poor in daily clinical practice. Barriers to implementation include clinical and organizational factors that might contribute to clinical inertia, i.e. avoidance/delay of recommended treatment initiation/optimization. The spectrum of strategies that might be applied to foster GDMT implementation is wide, and involves the organizational set-up of heart failure care pathways, tailored drug initiation/optimization strategies increasing the chance of successful implementation, digital tools/telehealth interventions, educational activities and strategies targeting patient/physician awareness, and use of quality registries. This scientific statement by the Heart Failure Association of the ESC provides an overview of the current state of GDMT implementation in HFrEF, clinical and organizational barriers to implementation, and aims at suggesting a comprehensive framework on how to overcome clinical inertia and ultimately improve implementation of GDMT in HFrEF based on up-to-date evidence.

• Jezik: Angleški jezik
• Ključne besede: clinical inertia, guideline-directed medical therapy, heart failure, heart failure with reduced ejection fraction, implementation
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.03 - Drugi znanstveni članki
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: Str. 1278-1297
• Številčenje: Vol. 26, no. 6
• PID: 20.500.12556/RUL-183024
• UDK: 616.1
• ISSN pri članku: 1388-9842
• DOI: 10.1002/ejhf.3295
• COBISS.SI-ID: 225693955
• Datum objave v RUL: 02.06.2026

Gradivo je del revije

• Naslov: European journal of heart failure
• Skrajšan naslov: Eur. j. heart fail.
• Založnik: Elsevier
• ISSN: 1388-9842
• COBISS.SI-ID: 1217301

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: klinična inercija, s smernicami usmerjena medicinska terapija, srčno popuščanje, srčno popuščanje z zmanjšanim iztisnim deležem, implementacija

Projekti

• Financer: Italy, Ministry of Health