20.500.12556/RUL-183024 How to tackle therapeutic inertia in heart failure with reduced ejection fraction a scientific statement of the Heart Failure Association of the ESC Guideline-directed medical therapy (GDMT) in patients with heart failure and reduced ejection fraction (HFrEF) reduces morbidity and mortality, but its implementation is often poor in daily clinical practice. Barriers to implementation include clinical and organizational factors that might contribute to clinical inertia, i.e. avoidance/delay of recommended treatment initiation/optimization. The spectrum of strategies that might be applied to foster GDMT implementation is wide, and involves the organizational set-up of heart failure care pathways, tailored drug initiation/optimization strategies increasing the chance of successful implementation, digital tools/telehealth interventions, educational activities and strategies targeting patient/physician awareness, and use of quality registries. This scientific statement by the Heart Failure Association of the ESC provides an overview of the current state of GDMT implementation in HFrEF, clinical and organizational barriers to implementation, and aims at suggesting a comprehensive framework on how to overcome clinical inertia and ultimately improve implementation of GDMT in HFrEF based on up-to-date evidence. clinical inertia guideline-directed medical therapy heart failure heart failure with reduced ejection fraction implementation klinična inercija s smernicami usmerjena medicinska terapija srčno popuščanje srčno popuščanje z zmanjšanim iztisnim deležem implementacija true false true Angleški jezik Slovenski jezik Članek v reviji 2026-06-02 08:47:45 2026-06-02 08:47:51 2026-07-20 16:22:28 0000-00-00 00:00:00 2024 0 0 Str. 1278-1297 no. 6 Vol. 26 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 1388-9842 10.1002/ejhf.3295 225693955 RAZ_Savarese_Gianluigi_2024.pdf RAZ_Savarese_Gianluigi_2024.pdf 1 EFC776CECC57827005A4870778F14640 200721d93e9f994ab18a4e4c72dc736c3b48649788fb1f5e3c0b4ae2d2c30f19 1741b18e-6578-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=235355 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.3295 1 9dfbb0c5-5e4e-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=234819 Medicinska fakulteta 0 0 0