Salience, sensemaking, and setting in psilocybin microdosing : methodological lessons and preliminary findings of a mixed method qualitative study

Oblak, Aleš (avtor), Hudnik Korošec, Liam (avtor), Levačić, Anja (avtor), Elersič, Kristian (avtor), Pregelj, Peter (avtor), Bon, Jurij (avtor)

There are profound methodological challenges facing microdosing research. One way we can address some of these methodological issues is by understanding how psilocybin microdosing fits in the broader existential context of people’s lives. We recruited participants who underwent psilocybin microdosing on their own and consented to being monitored for harm mitigation purposes. We combined momentary ecological assessment and detailed retrospective interviews. Participants reported loosening of mental structures (i.e., less intense strength of thoughts, tangential stream of consciousness), increased salience of external stimuli (varyingly associated with greater interest in otherwise mundane activities, as well as sensory overload), an increase in flexible cognition, a decrease in stable cognition, and various ego-dystonic contents. Highly structured environments were conducive to positive appraisal of experiences and vice versa. Momentary ecological assessment and retrospective interviews yielded differing accounts of microdosing experience. We relate our findings to stable and flexible cognition, as well as the notion of salience. We point out the necessity for systematic mixed methods studies to better characterize the lived experience of taking low doses of psilocybin.

• Jezik: Angleški jezik
• Ključne besede: psilocybin, microdosing, momentary ecological assessment, qualitative phenomenology, network model
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: Str. 3011-3037
• Številčenje: Vol. 38, no. 7
• PID: 20.500.12556/RUL-176012
• UDK: 616.89:616-092
• ISSN pri članku: 1465-394X
• DOI: 10.1080/09515089.2024.2393690
• COBISS.SI-ID: 211956739
• Datum objave v RUL: 18.11.2025

Gradivo je del revije

• Naslov: Philosophical psychology
• Založnik: Taylor & Francis
• ISSN: 1465-394X
• COBISS.SI-ID: 520632089

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: psilocibin, mikrodoziranje, trenutna ekološka ocena, kvantitativna fenomenologija, mrežni model