20.500.12556/RUL-176012 Salience, sensemaking, and setting in psilocybin microdosing methodological lessons and preliminary findings of a mixed method qualitative study There are profound methodological challenges facing microdosing research. One way we can address some of these methodological issues is by understanding how psilocybin microdosing fits in the broader existential context of people’s lives. We recruited participants who underwent psilocybin microdosing on their own and consented to being monitored for harm mitigation purposes. We combined momentary ecological assessment and detailed retrospective interviews. Participants reported loosening of mental structures (i.e., less intense strength of thoughts, tangential stream of consciousness), increased salience of external stimuli (varyingly associated with greater interest in otherwise mundane activities, as well as sensory overload), an increase in flexible cognition, a decrease in stable cognition, and various ego-dystonic contents. Highly structured environments were conducive to positive appraisal of experiences and vice versa. Momentary ecological assessment and retrospective interviews yielded differing accounts of microdosing experience. We relate our findings to stable and flexible cognition, as well as the notion of salience. We point out the necessity for systematic mixed methods studies to better characterize the lived experience of taking low doses of psilocybin. psilocybin microdosing momentary ecological assessment qualitative phenomenology network model psilocibin mikrodoziranje trenutna ekološka ocena kvantitativna fenomenologija mrežni model true false true Angleški jezik Slovenski jezik Članek v reviji 2025-11-18 10:15:28 2025-11-18 10:15:34 2025-12-16 04:09:59 0000-00-00 00:00:00 2025 0 0 Str. 3011-3037 no. 7 Vol. 38 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.89:616-092 1465-394X 10.1080/09515089.2024.2393690 211956739 Salience__sensemaking__and_setting_in_psilocybin_microdosing__Methodological_lessons_and_preliminary_findings_of_a_mixed_method_qualitative_study.pdf Salience__sensemaking__and_setting_in_psilocybin_microdosing__Methodological_lessons_and_preliminary_findings_of_a_mixed_method_qualitative_study.pdf 1 154BF4262539F936FA3CD468AA71B770 42a379ed0ddef4f100b45ec01af4cc824f5d5fff3067aa553d8da9db7db2eedb 14c438bf-c45f-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=222042 https://www.tandfonline.com/doi/full/10.1080/09515089.2024.2393690 0 fa4f4ab6-c45e-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=222041 Medicinska fakulteta 0 0 0