Coordination chemistry investigates structure, properties and formation of complexes in which a central metal ion is bound to ligands through coordination bonds. In this thesis, copper(II) was selected as the central metal ion and was coordinated with furosemide, a well-known diuretic drug containing carboxylic, amino and sulphonamide functional groups which are capable of binding to metal ions.
The experimental work focused on the synthesis of various copper(II) coordination compounds with furosemide and their characterization using different methods. Different reagents, solvents and reaction conditions were used (reactions at room temperature and in an autoclave at 105 °C), which enabled the preparation of different products. Among the synthesized compounds, the formation of the previously known complex [Cu(fur)$_2$(CH$_3$OH)$_2$] was confirmed, where deprotonated furosemide is coordinated in a monodentate manner via carboxylate oxygen. In other cases, compounds such as [Cu$_2$(fur)$_4$(CH$_3$CN)$_2$]∙2Et$_2$O, [Cu(quin)$_2$]$_n$∙2n(furH), and an unidentified compound X were obtained.
The isolated solid products were analyzed by infrared (IR) spectroscopy, CHN elemental analysis and thermogravimetric (TG) analysis. Some crystalline samples were also examined using single-crystal X-ray diffraction, which provided insight into compound composition, ligand coordination, and allowed crystal structure determination.
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