20.500.12556/RUL-171576 Koordinacijska kemija bakra(II) s furosemidom Copper(II) coordination chemistry with furosemide Koordinacijska kemija preučuje strukturo, lastnosti in nastanek kompleksov, v katerih se kovinski center povezuje z ligandi preko koordinacijskih vezi. V diplomskem delu smo kot kovinski center izbrali bakrov(II) ion, ki smo ga koordinirali s furosemidom, znanim diuretikom, ki vsebuje karboksilno, aminsko in sulfonamidno funkcionalno skupino, ki so sposobne vezave na kovinski ion. Eksperimentalni del je zajemal sintezo več bakrovih koordinacijskih spojin s furosemidom ter njihovo karakterizacijo z različnimi metodami. Pri tem smo uporabili različne reaktante, topila in reakcijske pogoje (reakcije pri sobni temperaturi in v avtoklavu pri 105 °C), kar je omogočilo pripravo različnih produktov. Med sinteznimi spojinami smo potrdili tvorbo že znane kompleksne spojine [Cu(fur)$_2$(CH$_3$OH)$_2$], kjer je deprotoniran furosemid koordiniran enovezno preko karboksilatnega kisika. V drugih primerih so nastale še spojine [Cu$_2$(fur)$_4$(CH$_3$CN)$_2$]∙2Et$_2$O, [Cu(quin)$_2$]$_n$∙2n(furH) in neznana spojina X. Izolirane trdne produkte smo analizirali z infrardečo spektroskopijo (IR), elementno CHN analizo in termogravimetrično (TG) analizo, nekatere pa tudi z rentgensko strukturno analizo na monokristalu. Te metode so nam omogočile vpogled v sestavo spojin, koordinacijo ligandov ter določitev kristalne strukture. Coordination chemistry investigates structure, properties and formation of complexes in which a central metal ion is bound to ligands through coordination bonds. In this thesis, copper(II) was selected as the central metal ion and was coordinated with furosemide, a well-known diuretic drug containing carboxylic, amino and sulphonamide functional groups which are capable of binding to metal ions. The experimental work focused on the synthesis of various copper(II) coordination compounds with furosemide and their characterization using different methods. Different reagents, solvents and reaction conditions were used (reactions at room temperature and in an autoclave at 105 °C), which enabled the preparation of different products. Among the synthesized compounds, the formation of the previously known complex [Cu(fur)$_2$(CH$_3$OH)$_2$] was confirmed, where deprotonated furosemide is coordinated in a monodentate manner via carboxylate oxygen. In other cases, compounds such as [Cu$_2$(fur)$_4$(CH$_3$CN)$_2$]∙2Et$_2$O, [Cu(quin)$_2$]$_n$∙2n(furH), and an unidentified compound X were obtained. The isolated solid products were analyzed by infrared (IR) spectroscopy, CHN elemental analysis and thermogravimetric (TG) analysis. Some crystalline samples were also examined using single-crystal X-ray diffraction, which provided insight into compound composition, ligand coordination, and allowed crystal structure determination. koordinacijska kemija baker furosemid coordination chemistry copper furosemide true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-08-28 10:25:02 2025-08-28 10:25:08 2025-09-07 04:07:18 0000-00-00 00:00:00 2025 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 25623 247863043 Pirnat_Masa_-_Koordinacijska_kemija_bakra(II)_s_furosemidom.pdf Pirnat_Masa_-_Koordinacijska_kemija_bakra(II)_s_furosemidom.pdf 1 9EBA8096BB85C2D6CDD2A5C8200AF7CD 1f583e4d1a6da6f427e9039a64ebf66235c0cab45e7bf241e22d153e0e9574ac 62c708dd-83e8-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=214940 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0