On zinc(II) coordination chemistry with furosemide : a journey from a mononuclear complex to a coordination polymer

Podjed Rihtaršič, Nina (avtor), Uranjek, Zarja (avtor), Cerc Korošec, Romana (avtor), Hrast, Martina (avtor), Golob, Majda (avtor), Modec, Barbara (avtor)

In continuation of our studies on zinc(II) coordination chemistry, reactions between the zinc(II) starting material and furosemide were investigated. Furosemide, a well-known pharmaceutical, contains functional groups which could serve as donors in coordination with metal ions. Reactions between zinc oxide or chloride and furosemide in aqueous ammonia solution yielded a mononuclear complex, [Zn(NH$_3$)$_2$(fur)$_2$] (1), where fur− stands for deprotonated furosemide. Unfortunately, some reactions produced mixtures of the desired metal complex 1 and by-product, ammonium salt NH$_4$fur (2). To further explore the coordination chemistry of furosemide, quinaldinate (an anion of quinoline-2-carboxylic acid, abbreviated as quin$^−$) was introduced into the reaction system, resulting in the formation of a coordination polymer, [Zn$_3$(quin)$_4$(fur)$_2$]$_n$·2nCH$_3$OH (3). 1 and 3 were evaluated for their antibacterial properties against Gram-positive and Gram-negative bacteria. Notably, compound 3 exhibited moderate antibacterial activity against Staphylococcus epidermidis, representing a promising starting point for the preparation of potential antibacterial zinc(II) complexes.

• Jezik: Angleški jezik
• Ključne besede: furosemide, quinaldinate, zinc(II), coordination compounds, polymer, crystal structure, antibacterial activity
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: Str. 9113-9122
• Številčenje: Vol. 49, iss. 22
• PID: 20.500.12556/RUL-169567
• UDK: 546.47
• ISSN pri članku: 1369-9261
• DOI: 10.1039/D5NJ01438G
• COBISS.SI-ID: 238212611
• Datum objave v RUL: 04.06.2025

Gradivo je del revije

• Naslov: New journal of chemistry
• Skrajšan naslov: New j. chem.
• Založnik: Royal Society of Chemistry
• ISSN: 1369-9261
• COBISS.SI-ID: 22573573

Licence

• Licenca: CC BY-NC 3.0, Creative Commons Priznanje avtorstva-Nekomercialno 3.0 Nedoločena
• Povezava: https://creativecommons.org/licenses/by-nc/3.0/deed.sl
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Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: furosemid, kinaldinat, cink(II), koordinacijske spojine, polimer, kristalna struktura, antibakterijska aktivnost