20.500.12556/RUL-169567 On zinc(II) coordination chemistry with furosemide a journey from a mononuclear complex to a coordination polymer In continuation of our studies on zinc(II) coordination chemistry, reactions between the zinc(II) starting material and furosemide were investigated. Furosemide, a well-known pharmaceutical, contains functional groups which could serve as donors in coordination with metal ions. Reactions between zinc oxide or chloride and furosemide in aqueous ammonia solution yielded a mononuclear complex, [Zn(NH$_3$)$_2$(fur)$_2$] (1), where fur$^−$ stands for deprotonated furosemide. Unfortunately, some reactions produced mixtures of the desired metal complex 1 and by-product, ammonium salt NH$_4$fur (2). To further explore the coordination chemistry of furosemide, quinaldinate (an anion of quinoline-2-carboxylic acid, abbreviated as quin$^−$) was introduced into the reaction system, resulting in the formation of a coordination polymer, [Zn$_3$(quin)$_4$(fur)$_2$]$_n$·2nCH$_3$OH (3). 1 and 3 were evaluated for their antibacterial properties against Gram-positive and Gram-negative bacteria. Notably, compound 3 exhibited moderate antibacterial activity against Staphylococcus epidermidis, representing a promising starting point for the preparation of potential antibacterial zinc(II) complexes. furosemide quinaldinate zinc(II) coordination compounds polymer crystal structure antibacterial activity furosemid kinaldinat cink(II) koordinacijske spojine polimer kristalna struktura antibakterijska aktivnost true false true Angleški jezik Slovenski jezik Članek v reviji 2025-06-04 12:17:52 2025-06-04 12:17:55 2026-01-27 04:23:10 0000-00-00 00:00:00 2025 0 0 Str. 9113-9122 iss. 22 Vol. 49 14 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 546.47 1369-9261 10.1039/D5NJ01438G 238212611 d5nj01438g.pdf d5nj01438g.pdf 1 35DE958FF90DE6C839C1853EB7C9562E 1878204410e3ed215eb684f527594bdfffce57e14f3827c1d915b456782b9d89 35f0674c-fac5-11f0-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=226213 https://pubs.rsc.org/en/content/articlelanding/2025/nj/d5nj01438g 1 ddedd121-412b-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=211042 Fakulteta za kemijo in kemijsko tehnologijo Fakulteta za farmacijo Veterinarska fakulteta 0 0 0