Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity : a systematic review and meta-analysis

Tratenšek, Armando (avtor), Locatelli, Igor (avtor), Grabnar, Iztok (avtor), Drobne, David (avtor), Vovk, Tomaž (avtor)

Oxidative stress is believed to play an important role in the pathogenesis of inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC). This meta-analysis aimed to identify and quantify the oxidative stress-related biomarkers in IBD and their associations with disease activity. We systematically searched Ovid MEDLINE, Ovid Embase, and Web of Science databases, identifying 54 studies for inclusion. Comparisons included: (I) active IBD versus healthy controls; (II) inactive IBD versus healthy controls; (III) active CD versus inactive CD; and (IV) active UC versus inactive UC. Our analysis revealed a significant accumulation of biomarkers of oxidative damage to biomacromolecules, coupled with reductions in various antioxidants, in both patients with active and inactive IBD compared to healthy controls. Additionally, we identified biomarkers that differentiate between active and inactive CD, including malondialdehyde, Paraoxonase 1, catalase, albumin, transferrin, and total antioxidant capacity. Similarly, levels of Paraoxonase 1, erythrocyte glutathione peroxidase, catalase, albumin, transferrin, and free thiols differed between active and inactive UC. Vitamins and carotenoids likewise emerged as potential disease activity biomarkers for CD and UC, but their intake should be monitored to obtain meaningful results. These findings emphasize the involvement of oxidative stress in the pathogenesis of IBD and highlight the potential of oxidative stress-related biomarkers as a minimally invasive and additional tool for monitoring the activity of IBD.

• Jezik: Angleški jezik
• Ključne besede: inflammatory bowel disease, ulcerative colitis, Crohn's disease, oxidative stress, biomarker, meta-analysis
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo ; MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 14 str.
• Številčenje: Vol. 77, art. 103380
• PID: 20.500.12556/RUL-163490
• UDK: 612.015:616.1/.4-036.1
• ISSN pri članku: 2213-2317
• DOI: 10.1016/j.redox.2024.103380
• COBISS.SI-ID: 209789443
• Datum objave v RUL: 07.10.2024

Gradivo je del revije

• Naslov: Redox biology
• Založnik: Elsevier
• ISSN: 2213-2317
• COBISS.SI-ID: 519722521

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: vnetna črevesna bolezen, biomarkerji, meta-analiza, oksidativni stres, Crohnova bolezen, kronične notranje bolezni, ulcerozni kolitis

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P1-0189
• Naslov: Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: J3-4499
• Naslov: MEHANIZMI ODZIVA NA IL 12/23 ZAVIRALCE PRI ULCEROZNEM KOLITISU - NAPROTI PERSONALIZIRANI MEDICINI