Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity : a systematic review and meta-analysis

Tratenšek, Armando (author), Locatelli, Igor (author), Grabnar, Iztok (author), Drobne, David (author), Vovk, Tomaž (author)

Oxidative stress is believed to play an important role in the pathogenesis of inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC). This meta-analysis aimed to identify and quantify the oxidative stress-related biomarkers in IBD and their associations with disease activity. We systematically searched Ovid MEDLINE, Ovid Embase, and Web of Science databases, identifying 54 studies for inclusion. Comparisons included: (I) active IBD versus healthy controls; (II) inactive IBD versus healthy controls; (III) active CD versus inactive CD; and (IV) active UC versus inactive UC. Our analysis revealed a significant accumulation of biomarkers of oxidative damage to biomacromolecules, coupled with reductions in various antioxidants, in both patients with active and inactive IBD compared to healthy controls. Additionally, we identified biomarkers that differentiate between active and inactive CD, including malondialdehyde, Paraoxonase 1, catalase, albumin, transferrin, and total antioxidant capacity. Similarly, levels of Paraoxonase 1, erythrocyte glutathione peroxidase, catalase, albumin, transferrin, and free thiols differed between active and inactive UC. Vitamins and carotenoids likewise emerged as potential disease activity biomarkers for CD and UC, but their intake should be monitored to obtain meaningful results. These findings emphasize the involvement of oxidative stress in the pathogenesis of IBD and highlight the potential of oxidative stress-related biomarkers as a minimally invasive and additional tool for monitoring the activity of IBD.

• Language: English
• Keywords: inflammatory bowel disease, ulcerative colitis, Crohn's disease, oxidative stress, biomarker, meta-analysis
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: 14 str.
• Numbering: Vol. 77, art. 103380
• PID: 20.500.12556/RUL-163490
• UDC: 612.015:616.1/.4-036.1
• ISSN on article: 2213-2317
• DOI: 10.1016/j.redox.2024.103380
• COBISS.SI-ID: 209789443
• Publication date in RUL: 07.10.2024

Record is a part of a journal

• Title: Redox biology
• Publisher: Elsevier
• ISSN: 2213-2317
• COBISS.SI-ID: 519722521

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: vnetna črevesna bolezen, biomarkerji, meta-analiza, oksidativni stres, Crohnova bolezen, kronične notranje bolezni, ulcerozni kolitis

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P1-0189
• Name: Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: J3-4499
• Name: MEHANIZMI ODZIVA NA IL 12/23 ZAVIRALCE PRI ULCEROZNEM KOLITISU - NAPROTI PERSONALIZIRANI MEDICINI