Estimation of direct interaction between membrane inclusions

Kralj-Iglič, Veronika (avtor)

Within the statistical mechanical description or the phospholipid bilayer membrane, each monolayer is described as composed of patches containing very many inclusions that are characterized by intrinsic curvatures. A patch is subjected to local membrane curvature whereas summing up the free energies of the patches yields the free energy of the membrane. The origin of the single inclusion energy is the mismatch between the intrinsic curvature of the inclusion and the local curvature of the membrane, however, also direct interactions between inclusions contribute to the free energy. Here we upgrade the description by elaborating direct interactions between inclusions. We assume that the direct interactions are subject to van der Waals forces acting on the interfaces between the inclusion and its nearest neighbours. The expression for the interaction depends on the geometry of the inclusions, distance between them and Hamaker constant. The estimated direct interaction between inclusions of the size of small membrane rafts (20 nm) distanced for 0.2 nm with Hamaker constant 710-21J is W1800 kT.

• Jezik: Angleški jezik
• Ključne besede: membrane free energy, membrane curvature, membrane shape, shape of the phospholipid membrane, membrane biophysics, hamaker constant
• Vrsta gradiva: Drugo
• Tipologija: 1.08 - Objavljeni znanstveni prispevek na konferenci
• Organizacija: ZF - Zdravstvena fakulteta
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: Str. 85-90
• PID: 20.500.12556/RUL-163379
• UDK: 577
• DOI: 10.55295/PSL.11.2024.10
• COBISS.SI-ID: 210332931
• Datum objave v RUL: 04.10.2024

Gradivo je del monografije

• Naslov: Socratic Lectures : 11th international symposium, Ljubljana, 8. June 2024
• Uredniki: Veronika Kralj-Iglič, Yelena Istileulova, Anna Romolo
• Kraj izida: Ljubljana
• Založnik: University of Ljubljana Press
• Leto izida: 2024
• ISBN: 978-961-297-383-4
• COBISS.SI-ID: 205044227

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: J3-3066-2021
• Naslov: Optimizacija s trombociti in zunajceličnimi vezikli bogate avtologne krvne plazme za zdravljenje pooperativnih ran v otorinolaringologiji

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P3-0388-2017
• Naslov: Mehanizmi varovanja zdravja