Estimation of direct interaction between membrane inclusions

Kralj-Iglič, Veronika (author)

Within the statistical mechanical description or the phospholipid bilayer membrane, each monolayer is described as composed of patches containing very many inclusions that are characterized by intrinsic curvatures. A patch is subjected to local membrane curvature whereas summing up the free energies of the patches yields the free energy of the membrane. The origin of the single inclusion energy is the mismatch between the intrinsic curvature of the inclusion and the local curvature of the membrane, however, also direct interactions between inclusions contribute to the free energy. Here we upgrade the description by elaborating direct interactions between inclusions. We assume that the direct interactions are subject to van der Waals forces acting on the interfaces between the inclusion and its nearest neighbours. The expression for the interaction depends on the geometry of the inclusions, distance between them and Hamaker constant. The estimated direct interaction between inclusions of the size of small membrane rafts (20 nm) distanced for 0.2 nm with Hamaker constant 710-21J is W1800 kT.

• Language: English
• Keywords: membrane free energy, membrane curvature, membrane shape, shape of the phospholipid membrane, membrane biophysics, hamaker constant
• Work type: Other
• Typology: 1.08 - Published Scientific Conference Contribution
• Organization: ZF - Faculty of Health Sciences
• Publication version: Version of Record
• Year: 2024
• Number of pages: Str. 85-90
• PID: 20.500.12556/RUL-163379
• UDC: 577
• DOI: 10.55295/PSL.11.2024.10
• COBISS.SI-ID: 210332931
• Publication date in RUL: 04.10.2024

Record is a part of a monograph

• Title: Socratic Lectures : 11th international symposium, Ljubljana, 8. June 2024
• Editors: Veronika Kralj-Iglič, Yelena Istileulova, Anna Romolo
• Place of publishing: Ljubljana
• Publisher: University of Ljubljana Press
• Year: 2024
• ISBN: 978-961-297-383-4
• COBISS.SI-ID: 205044227

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: J3-3066-2021
• Name: Optimizacija s trombociti in zunajceličnimi vezikli bogate avtologne krvne plazme za zdravljenje pooperativnih ran v otorinolaringologiji

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P3-0388-2017
• Name: Mehanizmi varovanja zdravja