The aim of my Master's thesis was to develop a comprehensive approach for the development of a potential anticancer active substance. This process includes the synthesis of an organic ligand, the formation of its metal complex, the preparation of a suitable nanocarrier and their mutual binding. The main objective was to develop and evaluate a system that combines chemical, biological and nanotechnological approaches for effective drug delivery to cancer cells. In this work, acid and ester derivatives of the pyrithione ligand were prepared. These compounds were then used as ligands in the synthesis of ruthenium(II) coordination compounds. Additionally, the prepared complexes were bound to mesoporous silica nanoparticles, MCM-41 and SBA-15, which were synthesized using a modified sol-gel process. The final product was characterized and prepared for potential biological testing of their anticancer activity.
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