20.500.12556/RUL-161058 Poskus vezave piritionskih derivatov in njihovih kovinskih kompleksov na izbrane nanonosilce Attempt of binding pyrithione derivatives and their metal complexes onto selected nanocarriers V okviru magistrske naloge sem želel izvesti celovit pristop k razvoju potencialne protirakave učinkovine, ki vključuje sintezo organskega liganda, tvorbo njegovega kovinskega kompleksa, pripravo primernega nanonosilca in njuno medsebojno vezavo. Glavni cilj je bil ustvariti in ovrednotiti sistem, ki združuje kemijske, biološke in nanotehnološke pristope za učinkovito dostavo zdravil do rakave celice. Pripravil sem kislinske in estrske derivate piritionskega liganda ter z njimi tvoril rutenijeve(II) komplekse. Te sem nato vezal na silicijeve mezoporozne nanodelce, MCM-41 in SBA-15, ki sem jih pripravil po modificiranem sol-gel postopku. Končni produkt sem okarakteriziral in pripravil za načrtovane biološke teste njihove protirakave aktivnosti. The aim of my Master's thesis was to develop a comprehensive approach for the development of a potential anticancer active substance. This process includes the synthesis of an organic ligand, the formation of its metal complex, the preparation of a suitable nanocarrier and their mutual binding. The main objective was to develop and evaluate a system that combines chemical, biological and nanotechnological approaches for effective drug delivery to cancer cells. In this work, acid and ester derivatives of the pyrithione ligand were prepared. These compounds were then used as ligands in the synthesis of ruthenium(II) coordination compounds. Additionally, the prepared complexes were bound to mesoporous silica nanoparticles, MCM-41 and SBA-15, which were synthesized using a modified sol-gel process. The final product was characterized and prepared for potential biological testing of their anticancer activity. nanodelci nanonosilci rutenijev kompleks piritionski ligand nanoparticles nanocarriers ruthenium complex pyrithione ligand true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2024-09-06 12:05:00 2024-09-06 12:05:05 2024-10-25 11:04:25 0000-00-00 00:00:00 2024 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 25305 212953603 Bertoncelj_Urh_-_Poskus_vezave_piritionskih_derivatov_in_njihovih_kovinskih_kompleksov_na_izbran.pdf Bertoncelj_Urh_-_Poskus_vezave_piritionskih_derivatov_in_njihovih_kovinskih_kompleksov_na_izbran.pdf 1 D197A448ABBEB8699D969BCD24C9EB06 397c45133fe4c52366c8e6a60053aa33462ce5b4042549f8500546f68bad7fe8 78cc2330-6c37-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=189917 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0