Influence of artificial sweeteners sodium saccharin and acesulfame potassium on the hydration properties and taste behavior of the antidiabetic drug metformin

Vukov, Andrija (avtor), Panić, Jovana (avtor), Bešter-Rogač, Marija (avtor), Vraneš, Milan (avtor)

Measurements of the density, sound velocity, and viscosity of metformin hydrochloride (MetHCl) solutions in water and 0.1 mol∙$kg^{−1}$ aqueous solution of sodium saccharin (Na-Sah) and acesulfame potassium (Ace-K) were carried out over the concentration range up ∼ 0.16 mol∙$kg^{−1}$ to MetHCl at nine temperatures T = (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15, 318.15) K. Several physicochemical properties of these systems were determined from the experimental data, including apparent molar volumes, apparent molar volumes at infinite dilution, finite apparent molar volumes of transfer, apparent specific volumes at infinite dilution, apparent molar isentropic compressibility at infinite dilution, hydration numbers, viscosity B coefficients, and thermodynamic parameters of viscous flow. The results were further discussed in terms of solute–solvent and solute–solute interactions to enlighten the interactions of metformin with artificial sweeteners in water and the possibility that artificial sweeteners mask the bitter taste of metformin.

• Jezik: Angleški jezik
• Ključne besede: metformin, artificial sweeteners, taste, density, viscosity, sound velocity
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 10 str.
• Številčenje: Vol. 399, art. 124353
• PID: 20.500.12556/RUL-154922
• UDK: 544.35
• ISSN pri članku: 0167-7322
• DOI: 10.1016/j.molliq.2024.124353
• COBISS.SI-ID: 188172803
• Datum objave v RUL: 08.03.2024

Gradivo je del revije

• Naslov: Journal of molecular liquids
• Skrajšan naslov: J. mol. liq.
• Založnik: Elsevier
• ISSN: 0167-7322
• COBISS.SI-ID: 15382277

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: metformin, umetna sladila, okus, gostota, viskoznost, hitrost zvoka