20.500.12556/RUL-154922 Influence of artificial sweeteners sodium saccharin and acesulfame potassium on the hydration properties and taste behavior of the antidiabetic drug metformin Measurements of the density, sound velocity, and viscosity of metformin hydrochloride (MetHCl) solutions in water and 0.1 mol•kg$^{−1}$ aqueous solution of sodium saccharin (Na-Sah) and acesulfame potassium (Ace-K) were carried out over the concentration range up ∼ 0.16 mol•kg$^{−1}$ to MetHCl at nine temperatures T = (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15, 318.15) K. Several physicochemical properties of these systems were determined from the experimental data, including apparent molar volumes, apparent molar volumes at infinite dilution, finite apparent molar volumes of transfer, apparent specific volumes at infinite dilution, apparent molar isentropic compressibility at infinite dilution, hydration numbers, viscosity B coefficients, and thermodynamic parameters of viscous flow. The results were further discussed in terms of solute–solvent and solute–solute interactions to enlighten the interactions of metformin with artificial sweeteners in water and the possibility that artificial sweeteners mask the bitter taste of metformin. metformin artificial sweeteners taste density viscosity sound velocity metformin umetna sladila okus gostota viskoznost hitrost zvoka true false true Angleški jezik Slovenski jezik Članek v reviji 2024-03-08 13:19:14 2024-03-08 13:19:16 2024-05-22 15:39:17 0000-00-00 00:00:00 2024 0 0 10 str. Vol. 399, art. 124353 1 Apr. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 544.35 0167-7322 10.1016/j.molliq.2024.124353 188172803 RAZ_Vukov_Andrija_2024.pdf RAZ_Vukov_Andrija_2024.pdf 1 A2DEEE462EBD6A80CB2021F9C5E8A24D 02663e43dc01f3cb7ad4ecb0b8d615cfe61c8a7435b41624bc933c772fc5340b 59e90692-dd48-11ee-b35c-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=181577 https://www.sciencedirect.com/science/article/pii/S0167732224004094 1 15314f93-dd46-11ee-b35c-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=181576 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0