Circulating tumor DNA methylation biomarkers for characterization and determination of the cancer origin in malignant liver tumors

Draškovič, Tina (avtor), Zidar, Nina (avtor), Hauptman, Nina (avtor)

Malignant liver tumors include primary malignant liver tumors and liver metastases. They are among the most common malignancies worldwide. The disease has a poor prognosis and poor overall survival, especially with liver metastases. Therefore, early detection and differentiation between malignant liver tumors are critical for patient treatment selection. The detection of cancer and the prediction of its origin is possible with a DNA methylation profile of the tumor DNA compared to that of normal cells, which reflects tissue differentiation and malignant transformation. New technologies enable the characterization of the tumor methylome in circulating tumor DNA (ctDNA), providing a variety of new ctDNA methylation biomarkers, which can provide additional information to clinical decision-making. Our review of the literature provides insight into methylation changes in ctDNA from patients with common malignant liver tumors and can serve as a starting point for further research.

• Jezik: Angleški jezik
• Ključne besede: malignant liver tumors, liver metastases, biopsy, primary malignant liver tumors, liquid biopsy, cell-free DNA, circulating tumor DNA, tissue of origin determination, DNA methylation
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: 21 str.
• Številčenje: Vol. 15, iss. 3, art. 859
• PID: 20.500.12556/RUL-154098
• UDK: 616-006
• ISSN pri članku: 2072-6694
• DOI: 10.3390/cancers15030859
• COBISS.SI-ID: 142286851
• Datum objave v RUL: 25.01.2024

Gradivo je del revije

• Naslov: Cancers
• Skrajšan naslov: Cancers
• Založnik: MDPI
• ISSN: 2072-6694
• COBISS.SI-ID: 517914137

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: maligni tumorji jeter, metastaze v jetrih, biopsija