20.500.12556/RUL-154098 Circulating tumor DNA methylation biomarkers for characterization and determination of the cancer origin in malignant liver tumors Malignant liver tumors include primary malignant liver tumors and liver metastases. They are among the most common malignancies worldwide. The disease has a poor prognosis and poor overall survival, especially with liver metastases. Therefore, early detection and differentiation between malignant liver tumors are critical for patient treatment selection. The detection of cancer and the prediction of its origin is possible with a DNA methylation profile of the tumor DNA compared to that of normal cells, which reflects tissue differentiation and malignant transformation. New technologies enable the characterization of the tumor methylome in circulating tumor DNA (ctDNA), providing a variety of new ctDNA methylation biomarkers, which can provide additional information to clinical decision-making. Our review of the literature provides insight into methylation changes in ctDNA from patients with common malignant liver tumors and can serve as a starting point for further research. malignant liver tumors liver metastases biopsy primary malignant liver tumors liquid biopsy cell-free DNA circulating tumor DNA tissue of origin determination DNA methylation maligni tumorji jeter metastaze v jetrih biopsija true false true Angleški jezik Slovenski jezik Članek v reviji 2024-01-25 09:00:03 2024-01-25 09:00:08 2024-01-27 03:16:38 0000-00-00 00:00:00 2023 0 0 21 str. iss. 3, art. 859 Vol. 15 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 2072-6694 10.3390/cancers15030859 142286851 cancers-15-00859-v3.pdf cancers-15-00859-v3.pdf 1 F28282235E17B8000FB173353D91EDD5 fc157dc9afe65634356194727c42a4c6b14f5e98a670b78c29fb943864305f28 8d3e68d8-bb58-11ee-9ead-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=180271 https://www.mdpi.com/2072-6694/15/3/859 1 c9afc68f-bb57-11ee-9ead-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=180270 Medicinska fakulteta 0 0 0