Correlating mechanical and rheological filament properties to processability and quality of 3D printed tablets using multiple linear regression

Kreft, Klemen (avtor), Lavrič, Zoran (avtor), Gradišar Centa, Urška (avtor), Mihelčič, Mohor (avtor), Slemenik Perše, Lidija (avtor), Dreu, Rok (avtor)

Filament formulation for FDM is a challenging and time-consuming process. Several pharmaceutical polymers are not feedable on their own. Due to inadequate filament formulation, 3D printed tablets can also exhibit poor uniformity of tablet attributes. To better understand filament formulation process, 23 filaments were prepared with the polymer mixing approach. To yield processable filaments, brittle and pliable polymers were combined. A 20 % addition of a pliable polymer to a brittle one resulted in filament processability and vice versa. Predictive statistical models for filament processability and uniformity of tablet attributes were established based on the mechanical and rheological properties of filaments. 15 input variables were correlated to 9 responses, which represent filament processability and tablet properties, by using multiple linear regression approach. Filament stiffness, assessed by indentation, and its square term were the only variables that determined the filament’s feedability. However, the resulting model is equipment-specific since different feeding mechanism exert different forces on the filaments. Additional models with good predictive power (R$^2$$ _pred$ > 0.50) were established for tablet width uniformity, drug release uniformity, tablet disintegration time uniformity and occurrence of disintegration, which are equipment-independent outputs. Therefore, the obtained model outcomes could be used in other research endeavours.

• Jezik: Angleški jezik
• Ključne besede: fused deposition modelling, personalized medicine, multiple linear regression, tablet quality attributes, correlation, 3D printing
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo ; FS - Fakulteta za strojništvo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 14 str.
• Številčenje: Vol. 651, art. 123719
• PID: 20.500.12556/RUL-154070
• UDK: 661.12:61-027.552
• ISSN pri članku: 0378-5173
• DOI: 10.1016/j.ijpharm.2023.123719
• COBISS.SI-ID: 182047747
• Datum objave v RUL: 23.01.2024

Gradivo je del revije

• Naslov: International journal of pharmaceutics
• Skrajšan naslov: Int. j. pharm.
• Založnik: Elsevier/North-Holland
• ISSN: 0378-5173
• COBISS.SI-ID: 3087631

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: modeliranje taljenega nanosa, personalizirana medicina, večkratna linearna regresija, atributi kakovosti tabličnega računalnika, korelacija, 3D tiskanje, farmacevtska tehnologija

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P1-0189
• Naslov: Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih