Sinteza kompleksov zlata z derivati piritiona

Brus, Anže (avtor), Turel, Iztok (mentor)

Kompleksi zlata se pospešeno preučujejo v medicini za zdravljenje različnih bolezni, med drugim tudi kot možne protirakave učinkovine. V zadnjih nekaj letih so raziskave o kompleksih zlata doživele razmah. Veliko je predvsem predkliničnih raziskav, v klinični rabi pa je trenutno samo en kompleks. Moj cilj je bil sintetizirati komplekse zlata(I) in zlata(III) z monometiliranimi piritioni (1-hidroksipiridin-2(1H)-tion). Najprej sem iz 2-bromometilpiridinov z oksidacijo in tiolacijo pripravil piritione z metilno skupino, ki sem jih nato uporabil za vezavo na zlatove(I) in zlatove(III) ione. Spojine sem okarakteriziral z jedrsko magnetno resonančno spektroskopijo (NMR), UV-Vis in IR spektroskopijo, visoko ločljivostno masno spektrometrijo (HRMS) ter CHN elementno analizo. Uspelo mi je pridobiti tudi kristale nekaterih spojin in z rentgensko difrakcijo na monokristalih določiti kristalne strukture treh kompleksov zlata(I).

• Jezik: Slovenski jezik
• Ključne besede: zlato, pirition, kovinski kompleks, sinteza, karakterizacija
• Vrsta gradiva: Magistrsko delo/naloga
• Tipologija: 2.09 - Magistrsko delo
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Leto izida: 2023
• PID: 20.500.12556/RUL-149155
• COBISS.SI-ID: 167743491
• Datum objave v RUL: 04.09.2023

Sekundarni jezik

• Jezik: Angleški jezik
• Naslov: Synthesis of gold complexes with pyrithione derivatives

Izvleček

Gold complexes are rapidly being investigated in medicine for the treatment of various diseases, including as potential anticancer agents. In the last few years, studies on gold complexes have experienced a surge. There is a large amount of pre-clinical research, but only one complex is currently in clinical use. My aim was to synthesize gold(I) and gold(III) complexes with monomethylated pyrithiones (1-hydroxypyridine-2(1H)-thione). First, I prepared pyrithiones with a methyl group from 2-bromomethylpyridines by oxidation and thiolation reactions, which were then used to bind to gold(I) and gold(III) ions. The compounds were characterized by nuclear magnetic resonance spectroscopy (NMR), UV-Vis and IR spectroscopy, high-resolution mass spectrometry (HRMS), and CHN elemental analysis. I was also able to obtain crystals of some compounds and to determine the crystal structures of three gold(I) complexes by X-ray diffraction on single crystals.

• Ključne besede: gold, pyrithione, metal complex, synthesis, characterization