20.500.12556/RUL-149155 Sinteza kompleksov zlata z derivati piritiona Synthesis of gold complexes with pyrithione derivatives Kompleksi zlata se pospešeno preučujejo v medicini za zdravljenje različnih bolezni, med drugim tudi kot možne protirakave učinkovine. V zadnjih nekaj letih so raziskave o kompleksih zlata doživele razmah. Veliko je predvsem predkliničnih raziskav, v klinični rabi pa je trenutno samo en kompleks. Moj cilj je bil sintetizirati komplekse zlata(I) in zlata(III) z monometiliranimi piritioni (1-hidroksipiridin-2(1H)-tion). Najprej sem iz 2-bromometilpiridinov z oksidacijo in tiolacijo pripravil piritione z metilno skupino, ki sem jih nato uporabil za vezavo na zlatove(I) in zlatove(III) ione. Spojine sem okarakteriziral z jedrsko magnetno resonančno spektroskopijo (NMR), UV-Vis in IR spektroskopijo, visoko ločljivostno masno spektrometrijo (HRMS) ter CHN elementno analizo. Uspelo mi je pridobiti tudi kristale nekaterih spojin in z rentgensko difrakcijo na monokristalih določiti kristalne strukture treh kompleksov zlata(I). Gold complexes are rapidly being investigated in medicine for the treatment of various diseases, including as potential anticancer agents. In the last few years, studies on gold complexes have experienced a surge. There is a large amount of pre-clinical research, but only one complex is currently in clinical use. My aim was to synthesize gold(I) and gold(III) complexes with monomethylated pyrithiones (1-hydroxypyridine-2(1H)-thione). First, I prepared pyrithiones with a methyl group from 2-bromomethylpyridines by oxidation and thiolation reactions, which were then used to bind to gold(I) and gold(III) ions. The compounds were characterized by nuclear magnetic resonance spectroscopy (NMR), UV-Vis and IR spectroscopy, high-resolution mass spectrometry (HRMS), and CHN elemental analysis. I was also able to obtain crystals of some compounds and to determine the crystal structures of three gold(I) complexes by X-ray diffraction on single crystals. zlato pirition kovinski kompleks sinteza karakterizacija gold pyrithione metal complex synthesis characterization true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2023-09-04 14:45:00 2023-09-04 14:45:02 2023-10-10 10:38:55 0000-00-00 00:00:00 2023 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 21954 167743491 Brus_Anze_-_Sinteza_kompleksov_zlata_z_derivati_piritiona.pdf Brus_Anze_-_Sinteza_kompleksov_zlata_z_derivati_piritiona.pdf 1 624459A224586BC6096409B6592C5B01 87368262c44c1e9499f0038cef6530bd5428d032343283a1f5f400d7a67c6ca8 db0cba04-4b20-11ee-af86-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=173550 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0