Molecular mechanisms related to responses to oxidative stress and antioxidative therapies in COVID-19 : a systematic review

Tsermpini, Evangelia Eirini (avtor), Glamočlija, Una (avtor), Ulucan-Karnak, Fulden (avtor), Redenšek Trampuž, Sara (avtor), Dolžan, Vita (avtor)

The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease’s progression is not entirely understood, but there are strong indications that oxidative stress and the defense against reactive oxygen species are crucial players. A big influx of immune cells to the site of infection is marked by the increase in reactive oxygen and nitrogen species. Our article aims to highlight the critical role of oxidative stress in the emergence and severity of COVID-19 and, more importantly, to shed light on the underlying molecular and genetic mechanisms. We have reviewed the available literature and clinical trials to extract the relevant genetic variants within the oxidative stress pathway associated with COVID-19 and the anti-oxidative therapies currently evaluated in the clinical trials for COVID-19 treatment, in particular clinical trials on glutathione and N-acetylcysteine.

• Jezik: Angleški jezik
• Ključne besede: COVID-19, oxidative stress, genetics, antioxidant enzymes, anti-oxidative therapies, glutathione, N-acetylcysteine
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 37 str.
• Številčenje: Vol. 11, iss. 8, art. 1609
• PID: 20.500.12556/RUL-145247
• UDK: 616.9
• ISSN pri članku: 2076-3921
• DOI: 10.3390/antiox11081609
• COBISS.SI-ID: 118709507
• Datum objave v RUL: 13.04.2023

Gradivo je del revije

• Naslov: Antioxidants
• Skrajšan naslov: Antioxidants
• Založnik: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: COVID-19, oksidativni stres, genetika

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0170
• Naslov: Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku