20.500.12556/RUL-145247 Molecular mechanisms related to responses to oxidative stress and antioxidative therapies in COVID-19 a systematic review The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease’s progression is not entirely understood, but there are strong indications that oxidative stress and the defense against reactive oxygen species are crucial players. A big influx of immune cells to the site of infection is marked by the increase in reactive oxygen and nitrogen species. Our article aims to highlight the critical role of oxidative stress in the emergence and severity of COVID-19 and, more importantly, to shed light on the underlying molecular and genetic mechanisms. We have reviewed the available literature and clinical trials to extract the relevant genetic variants within the oxidative stress pathway associated with COVID-19 and the anti-oxidative therapies currently evaluated in the clinical trials for COVID-19 treatment, in particular clinical trials on glutathione and N-acetylcysteine. COVID-19 oxidative stress genetics antioxidant enzymes anti-oxidative therapies glutathione N-acetylcysteine COVID-19 oksidativni stres genetika true false true Angleški jezik Slovenski jezik Članek v reviji 2023-04-13 15:28:54 2023-04-13 15:28:56 2023-04-14 03:50:00 0000-00-00 00:00:00 2022 0 0 37 str. iss. 8, art. 1609 Vol. 11 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2076-3921 10.3390/antiox11081609 118709507 antioxidants-11-01609-v3.pdf antioxidants-11-01609-v3.pdf 1 7B9EBDB05C79753A4E93144311ED9983 d97e40179b4cf9d0399ca8783ebe19b8872fa32ff54f206a00e67f5999731464 28ffc0bb-d9ff-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167983 https://www.mdpi.com/2076-3921/11/8/1609 1 fe1277c8-d9fe-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167982 Medicinska fakulteta 0 0 0