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Decrease in cellular nanovesicles concentration in blood of athletes more than 15 hours after marathon
ID Jan, Zala (Avtor), ID Drab, Mitja (Avtor), ID Drobne, Damjana (Avtor), ID Bedina Zavec, Apolonija (Avtor), ID Benčina, Mojca (Avtor), ID Drašler, Barbara (Avtor), ID Hočevar, Matej (Avtor), ID Krek, Judita Lea (Avtor), ID Pađen, Ljubiša (Avtor), ID Pajnič, Manca (Avtor), ID Repar, Neža (Avtor), ID Šimunič, Boštjan (Avtor), ID Štukelj, Roman (Avtor), ID Kralj-Iglič, Veronika (Avtor)

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Izvleček
Introduction: Cellular nanovesicles (CNVs), that are shed from cells, have been recognized as promising indicators of health status. We analyzed the effect of long-distance running on concentration of CNVs, along with some standard blood parameters, in 27 athletes two days before and >15 hours after physical effort. Methods: CNVs were isolated by repetitive centrifugation and washing of samples, and assessed by flow cytometry. Cholinesterase (ChE) and glutathione S-transferase (GST) activity were measured spectrophotometrically. Interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations were measured using enzyme-linked immunosorbent assay (ELISA). C-reactive protein (CRP) was measured with immunoturbidimetric determination and lipidogram parameters were measured by enzymatic colorimetric assay. Flow cytometry was used for blood cell count and mean platelet volume (MPV) measurement. Results: More than 15 hours after physical effort a decrease was found in CNVs’ concentration in isolates from blood (46%; p0.8; p<0.05), in ChE activity in whole blood (47%; p<0.001), in plasma (34%; p<0.01), and in erythrocyte suspension (54%; p<0.001), as well as in GST activity in erythrocyte suspension (16%; p<0.01) and in IL-6 concentration in plasma (63%; p<0.05). We found no change in GST activity in plasma and in TNF-α concentration in plasma. Correlations (>0.8; p<0.001) between CNVs’ concentration and ChE activity, and GST activity, respectively, in erythrocyte suspension were found. Conclusion: We found that > 15 hours post-physical effort, CNVs’ concentration was below the initial value, concomitant with other measured parameters: ChE and GST activity as well as IL-6 concentration, indicating a favorable effect of physical effort on health status. CNVs’ concentration and ChE activity in isolates from peripheral blood proved to have potential as indicators of the response of the human body to inflammation after physical effort. Physical activity should be considered as an important factor in preparation of subjects for blood sampling in procedures focusing on CNV-containing diagnostic and therapeutic compounds.

Jezik:Angleški jezik
Ključne besede:membrane vesiculation, physical effort, blood samples, inflammation process, cellular nanovesicles, marathon
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:ZF - Zdravstvena fakulteta
FE - Fakulteta za elektrotehniko
BF - Biotehniška fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2021
Št. strani:Str. 443-456
Številčenje:Vol. 16
PID:20.500.12556/RUL-144718 Povezava se odpre v novem oknu
UDK:577.1:796.422.16
ISSN pri članku:1178-2013
DOI:10.2147/IJN.S282200 Povezava se odpre v novem oknu
COBISS.SI-ID:48113411 Povezava se odpre v novem oknu
Datum objave v RUL:09.03.2023
Število ogledov:343
Število prenosov:56
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:International journal of nanomedicine
Založnik:Dove Medical Press
ISSN:1178-2013
COBISS.SI-ID:3223828 Povezava se odpre v novem oknu

Licence

Licenca:CC BY-NC 3.0, Creative Commons Priznanje avtorstva-Nekomercialno 3.0 Nedoločena
Povezava:https://creativecommons.org/licenses/by-nc/3.0/deed.sl
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Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:vezikulacija membrane, fizični napor, krvni vzorci, vnetni procesi, celični nanovezikli, maraton

Projekti

Financer:EC - European Commission
Program financ.:H2020
Številka projekta:801338
Naslov:Extracellular vesicles from a natural source for tailor-made nanomaterials
Akronim:VES4US

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0388
Naslov:Mehanizmi varovanja zdravja

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J1-9162
Naslov:Neurotoksičnost ali neuroprotektivnost nanomaterialov: vpliv biokorone

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