izpis_h1_title_alt

Antibody arrays identified cycle-dependent plasma biomarker candidates of peritoneal endometriosis
ID Pušić Novak, Maja (Avtor), ID Klančič, Teja (Avtor), ID Knific, Tamara (Avtor), ID Vogler, Andrej (Avtor), ID Schmidt, Ronny (Avtor), ID Schröder, Christoph (Avtor), ID Lanišnik-Rižner, Tea (Avtor)

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URLURL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2075-4426/12/6/852 Povezava se odpre v novem oknu

Izvleček
Endometriosis is an estrogen-dependent inflammatory disease affecting women in their reproductive age. Due to non-specific symptoms, women with endometriosis are often misdiagnosed or are accurately diagnosed only after several years. Diagnosis of peritoneal endometriosis is especially challenging and relies only on laparoscopic surgery. To date, different molecules have been proposed as potential non-invasive biomarkers of endometriosis; however, none have been confirmed as clinically useful. Therefore, this study aimed to discover novel plasma biomarker candidates for peritoneal endometriosis using an antibody array platform. This study included patients with endometriosis-like symptoms characterized by the absence (controls) or presence of peritoneal endometriosis (cases) after laparoscopic surgery and histological evaluation. Patients were further divided into secretory and proliferative groups, according to the phase of their menstrual cycle. Their plasma samples were collected and analyzed on an antibody array platform targeting more than 1350 proteins with over 1820 antibodies. In the proliferative group, the analysis revealed three differential proteins between cases and controls: ITB3, ITA2B2, and ACVL-1. In the secretory group, none of the examined proteins reached the log-fold change (logFC) and significance thresholds simultaneously. The potential of the identified differential proteins as plasma biomarker candidates for peritoneal endometriosis should be evaluated on a larger cohort, and their role in endometriosis should be investigated in further studies.

Jezik:Angleški jezik
Ključne besede:peritoneal endometriosis, antibody arrays, biomarkers, integrins, proteomics, discovery, menstrual phase
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2022
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:16 str.
Številčenje:Vol. 12, iss. 6, art. 852
PID:20.500.12556/RUL-143964 Povezava se odpre v novem oknu
UDK:618.1
ISSN pri članku:2075-4426
DOI:10.3390/jpm12060852 Povezava se odpre v novem oknu
COBISS.SI-ID:109358595 Povezava se odpre v novem oknu
Datum objave v RUL:24.01.2023
Število ogledov:51
Število prenosov:33
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Journal of personalized medicine
Skrajšan naslov:J. pers. med.
Založnik:MDPI
ISSN:2075-4426
COBISS.SI-ID:31207641 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:peritonealna endometrioza, nizi protiteles, biomarkerji

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Program financ.:Young Researchers

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J3-1755
Naslov:Biokemijski označevalci endometrioze: študije transkriptoma in proteoma

Financer:EC - European Commission
Program financ.:H2020
Številka projekta:101008193
Naslov:Translational Research on Endometriosis
Akronim:TRENDO

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