20.500.12556/RUL-143964
Antibody arrays identified cycle-dependent plasma biomarker candidates of peritoneal endometriosis
Endometriosis is an estrogen-dependent inflammatory disease affecting women in their reproductive age. Due to non-specific symptoms, women with endometriosis are often misdiagnosed or are accurately diagnosed only after several years. Diagnosis of peritoneal endometriosis is especially challenging and relies only on laparoscopic surgery. To date, different molecules have been proposed as potential non-invasive biomarkers of endometriosis; however, none have been confirmed as clinically useful. Therefore, this study aimed to discover novel plasma biomarker candidates for peritoneal endometriosis using an antibody array platform. This study included patients with endometriosis-like symptoms characterized by the absence (controls) or presence of peritoneal endometriosis (cases) after laparoscopic surgery and histological evaluation. Patients were further divided into secretory and proliferative groups, according to the phase of their menstrual cycle. Their plasma samples were collected and analyzed on an antibody array platform targeting more than 1350 proteins with over 1820 antibodies. In the proliferative group, the analysis revealed three differential proteins between cases and controls: ITB3, ITA2B2, and ACVL-1. In the secretory group, none of the examined proteins reached the log-fold change (logFC) and significance thresholds simultaneously. The potential of the identified differential proteins as plasma biomarker candidates for peritoneal endometriosis should be evaluated on a larger cohort, and their role in endometriosis should be investigated in further studies.
peritoneal endometriosis
antibody arrays
biomarkers
integrins
proteomics
discovery
menstrual phase
peritonealna endometrioza
nizi protiteles
biomarkerji
true
false
true
Angleški jezik
Slovenski jezik
Članek v reviji
2023-01-24 16:34:34
2023-01-24 16:34:40
2023-01-27 03:35:33
0000-00-00 00:00:00
2022
0
0
16 str.
iss. 6, art. 852
Vol. 12
2022
0000-00-00
Zaloznikova
Objavljeno
NiDoloceno
0000-00-00
0000-00-00
0000-00-00
618.1
2075-4426
10.3390/jpm12060852
109358595
RAZ_Pusic_Novak_Maja_2022.pdf
RAZ_Pusic_Novak_Maja_2022.pdf
1
F9966B2B82C6B686E486518E8E24ACCE
ab9654182c2d41c21f626136703f6a6d2ea399a04206bd6350789f5db5f53b25
5d1afb5e-9bfc-11ed-9c94-00155dcfd717
https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=166052
https://www.mdpi.com/2075-4426/12/6/852
0
b2a75fb2-9bfd-11ed-9c94-00155dcfd717
https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=166053
Medicinska fakulteta
0
0
0