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Bisphenol A in edible tissues of rams exposed to repeated low-level dietary dose by high-performance liquid chromatography with fluorescence detection
ID
Cerkvenik, Vesna
(
Avtor
),
ID
Škibin, Andrej
(
Avtor
),
ID
Švara, Tanja
(
Avtor
),
ID
Gombač, Mitja
(
Avtor
),
ID
Pogačnik, Milan
(
Avtor
),
ID
Šturm, Sabina
(
Avtor
)
PDF - Predstavitvena datoteka,
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(903,76 KB)
MD5: 189463BFA26166F5D3C3A23B43155959
URL - Izvorni URL, za dostop obiščite
https://link.springer.com/article/10.1007/s11356-022-21154-5
Galerija slik
Izvleček
The presented work deals with levels and distribution of bisphenol A (BPA) in the edible tissues of a large food-producing animal species. An experimental animal study included 14 young Istrian pramenka rams (Ovis aries), of which seven were exposed for 64 days to a low dietary dose of BPA at 25 µg/kg b.w./day, and seven served as a control group. Residue analysis of both aglycone and total BPA was performed in the muscle tissue, liver, kidney and fat tissue of the individual animals by means of enzymatic deconjugation (for total BPA), organic solvent extraction, molecularly imprinted polymer solid-phase extraction (MISPE) clean-up and high-performance liquid chromatography with fluorescence detection (HPLC-FLU). The analysis was optimized and validated for aglycone BPA in the fat tissue and for the total BPA in all tissues investigated. Edible tissues of the control group of rams generally remained BPA-free, while there were concentration differences between the control and treated groups for liver and kidney post last administration. The human health risk resulting from this study was assessed by the estimated dietary exposure in adults, which was < 0.1% related to the valid European Union Tolerable Daily Intake (TDI) value of 4 µg/kg b.w./day. However, it would be 58-fold higher than the newly proposed TDI value of 0.04 ng/kg b.w./day.
Jezik:
Angleški jezik
Ključne besede:
Bisphenol A
,
Total bisphenol A
,
Sheep
,
Tissues
,
Distribution
,
HPLC-fluorescence
,
Risk assessment
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
VF - Veterinarska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
Str. 76078-76090
Številčenje:
Vol. 29, no. 50
PID:
20.500.12556/RUL-143570
UDK:
636.09:615.9
ISSN pri članku:
1614-7499
DOI:
10.1007/s11356-022-21154-5
COBISS.SI-ID:
110581763
Datum objave v RUL:
28.12.2022
Število ogledov:
468
Število prenosov:
54
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Objavi na:
Gradivo je del revije
Naslov:
Environmental science and pollution research
Skrajšan naslov:
Environ. sci. pollut. res. int.
Založnik:
Springer Nature, European Chemical Society, Division of Chemistry and the Environment
ISSN:
1614-7499
COBISS.SI-ID:
512607257
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0092
Naslov:
Zdravje živali, okolje in varna hrana
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