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Association of Zn and Cu levels in cord blood and maternal milk with pregnancy outcomes among the Slovenian population
ID Osredkar, Joško (Avtor), ID Geršak, Živa Miriam (Avtor), ID Karas Kuželički, Nataša (Avtor), ID Snoj Tratnik, Janja (Avtor), ID Mazej, Darja (Avtor), ID Falnoga, Ingrid (Avtor), ID Horvat, Milena (Avtor), ID Geršak, Ksenija (Avtor)

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Izvleček
Trace elements, including zinc (Zn) and copper (Cu), are known to play important roles in human health. The present study aimed to assess the levels of Zn and Cu in cord blood and maternal milk and to analyze their association with maternal and infant characteristics and pregnancy outcomes in a Slovenian study population of mothers and their neonates recruited within the PHIME prospective cohort study. The study included 324 mothers, but the data on Zn and Cu levels in both cord blood and maternal milk was available for 243 mothers. Questionnaires were used to assess the socio-demographic and health status of the mothers, their lifestyle habits (including detailed nutritional habits), and their residential and occupational histories. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used to measure Zn and Cu levels in cord blood and maternal milk. Low Zn levels in cord blood were associated with lower gestational age and birth weight and were correlated with an increased probability of the birth of small for gestational age (SGA) infants. Maternal smoking influenced the Cu levels in both cord blood and maternal milk. Cord blood Cu levels were higher and Cu levels in maternal milk were lower in smoking compared to non-smoking mothers. Most importantly, a decreased Zn/Cu ratio in cord blood was associated with lower gestational age and lower birth weight. This indicates the overall positive effects of Zn and negative effects of Cu on pregnancy outcomes.

Jezik:Angleški jezik
Ključne besede:cord blood, maternal milk, gestational age, birth weight
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2022
Št. strani:Str. 1-19
Številčenje:Vol. 14, no. 21, art. 4667
PID:20.500.12556/RUL-142400 Povezava se odpre v novem oknu
UDK:618.2/.7
ISSN pri članku:2072-6643
DOI:10.3390/nu14214667 Povezava se odpre v novem oknu
COBISS.SI-ID:128037379 Povezava se odpre v novem oknu
Datum objave v RUL:07.11.2022
Število ogledov:379
Število prenosov:58
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Nutrients
Skrajšan naslov:Nutrients
Založnik:MDPI
ISSN:2072-6643
COBISS.SI-ID:2948140 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:popkovnična kri, materino mleko, gestacijska starost, porodna teža

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0124-2020
Naslov:Metabolni in prirojeni dejavniki reproduktivnega zdravja, porod III

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P1-0143-2020
Naslov:Kroženje snovi v okolju, snovna bilanca in modeliranje okoljskih procesov ter ocena tveganja

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