20.500.12556/RUL-142400 Association of Zn and Cu levels in cord blood and maternal milk with pregnancy outcomes among the Slovenian population Trace elements, including zinc (Zn) and copper (Cu), are known to play important roles in human health. The present study aimed to assess the levels of Zn and Cu in cord blood and maternal milk and to analyze their association with maternal and infant characteristics and pregnancy outcomes in a Slovenian study population of mothers and their neonates recruited within the PHIME prospective cohort study. The study included 324 mothers, but the data on Zn and Cu levels in both cord blood and maternal milk was available for 243 mothers. Questionnaires were used to assess the socio-demographic and health status of the mothers, their lifestyle habits (including detailed nutritional habits), and their residential and occupational histories. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used to measure Zn and Cu levels in cord blood and maternal milk. Low Zn levels in cord blood were associated with lower gestational age and birth weight and were correlated with an increased probability of the birth of small for gestational age (SGA) infants. Maternal smoking influenced the Cu levels in both cord blood and maternal milk. Cord blood Cu levels were higher and Cu levels in maternal milk were lower in smoking compared to non-smoking mothers. Most importantly, a decreased Zn/Cu ratio in cord blood was associated with lower gestational age and lower birth weight. This indicates the overall positive effects of Zn and negative effects of Cu on pregnancy outcomes. cord blood maternal milk gestational age birth weight popkovnična kri materino mleko gestacijska starost porodna teža true false true Angleški jezik Slovenski jezik Članek v reviji 2022-11-07 07:34:47 2022-11-07 07:34:54 2022-11-08 03:56:52 0000-00-00 00:00:00 2022 0 0 Str. 1-19 no. 21, art. 4667 Vol. 14 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.2/.7 2072-6643 10.3390/nu14214667 128037379 nutrients-14-04667.pdf nutrients-14-04667.pdf 1 38B602DC7CDA3470E240E48795CD85EC d1a7dfa6f03b8261deb71121eaab82cc757628e3f75e64c831e4a6acaf6d4f3e 7c004829-5e66-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163742 https://www.mdpi.com/2072-6643/14/21/4667 1 32bf8d55-5e66-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163741 Fakulteta za farmacijo Medicinska fakulteta 0 0 0