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Comparison of the robustness of pellet film coating with and without in-process coating thickness evaluation
ID Brezovar, Teja (Avtor), ID Svetič, Sandi (Avtor), ID Dreu, Rok (Avtor)

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Izvleček
The robustness of the pellet coating process with and without the use of an in-process coating thickness analyzer (PATVIS APA) was investigated. Pellets containing model drug were coated with a prolonged release film coating, using different process conditions. In the first set of experiments film coating was performed as process repetitions with unintentional variation of process parameters, and in the second set, controlled changes (inlet air humidity, gap between distribution plate and Wurster partition, starting pellet load) were made. Within the first set of experiments, the coating process endpoint was determined either via gravimetric consumption of coating dispersion or by means of in-line coating thickness monitoring. The release profiles of the pellets were analyzed and the density of coating calculated. Both methods of the process endpoint determination can be relatively robust in batch processing, if key factors influencing drug release profile are under control. PATVIS APA was shown to be a useful tool to better understand the coating process and can be helpful if coating process interruptions are encountered. Water content was shown to be the key factor influencing the drug profile, presumably by influencing the structure and thickness of the coating applied.

Jezik:Angleški jezik
Ključne besede:pellets, coating of pellets, prolonged release coating, PAT, image analysis, residual water
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2022
Št. strani:16 str.
Številčenje:Vol. 14, iss. 11, art. 2274
PID:20.500.12556/RUL-142209 Povezava se odpre v novem oknu
UDK:661.12:615.454
ISSN pri članku:1999-4923
DOI:10.3390/pharmaceutics14112274 Povezava se odpre v novem oknu
COBISS.SI-ID:127052291 Povezava se odpre v novem oknu
Datum objave v RUL:25.10.2022
Število ogledov:943
Število prenosov:64
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Gradivo je del revije

Naslov:Pharmaceutics
Skrajšan naslov:Pharmaceutics
Založnik:MDPI
ISSN:1999-4923
COBISS.SI-ID:517949977 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:pelete, oblaganje pelet, premaz s podaljšanim sproščanjem, PAT, analiza slike, preostala voda

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P1-0189-2018
Naslov:Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih

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