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Lactic acid bacteria and bifidobacteria deliberately introduced into the agro-food chain do not significantly increase the antimicrobial resistance gene pool
ID Rozman, Vita (Avtor), ID Mohar Lorbeg, Petra (Avtor), ID Treven, Primož (Avtor), ID Accetto, Tomaž (Avtor), ID Golob, Majda (Avtor), ID Zdovc, Irena (Avtor), ID Bogovič Matijašić, Bojana (Avtor)

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URLURL - Izvorni URL, za dostop obiščite https://www.tandfonline.com/doi/full/10.1080/19490976.2022.2127438 Povezava se odpre v novem oknu

Izvleček
Lactic acid bacteria (LAB) and bifidobacteria may serve as reservoirs of antimicrobial resistance, but the risk posed by strains intentionally introduced into the agro-food chain has not yet been thoroughly investigated. The aim of our study was to evaluate whether probiotics, starter and protective cultures, and feed additives represent a risk to human health. In addition to commercial strains of LAB and bifidobacteria, isolates from human milk or colostrum, intestinal mucosa or feces, and fermented products were analyzed. Phenotypic susceptibility data of 474 strains showed that antimicrobial resistance was more common in intestinal isolates than in commercial strains. Antimicrobial resistance genes (ARGs) and mobile genetic elements (MGEs) were characterized in the whole genome sequences of 1114 strains using comparative genomics. Intrinsic ARGs were abundant in enterococci, bifidobacteria, and lactococci but were considered non-risky due to the absence of MGEs. The results revealed that 13.8% of commercial strains contained acquired ARGs, most frequently for tetracycline. We associated 75.5% of the acquired ARGs with known or novel MGEs, and their potential for transmission was assessed by examining metagenomic sequences. We confirmed that ARGs and MGEs were not as abundant or diverse in commercial strains as in human intestinal isolates or isolates from human milk, suggesting that strains intentionally introduced into the agro-food chain do not pose a significant threat. However, attention should be paid especially to individual probiotic strains containing elements that have been shown to have high potential for transferability in the gut microbiota.

Jezik:Angleški jezik
Ključne besede:Lactic acid bacteria, bifidobacteria, probiotic, starter culture, antimicrobial resistance, resistance gene, mobile genetic element, metagenomes, whole genome sequences
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:BF - Biotehniška fakulteta
VF - Veterinarska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2022
Št. strani:17 str.
Številčenje:Vol. 14, no. 1, art. e2127438
PID:20.500.12556/RUL-141922 Povezava se odpre v novem oknu
UDK:579:575
ISSN pri članku:1949-0984
DOI:10.1080/19490976.2022.2127438 Povezava se odpre v novem oknu
COBISS.SI-ID:123511555 Povezava se odpre v novem oknu
Datum objave v RUL:11.10.2022
Število ogledov:413
Število prenosov:106
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Gradivo je del revije

Naslov:Gut microbes
Založnik:Taylor & Francis
ISSN:1949-0984
COBISS.SI-ID:522490137 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:mikrobiologija, mlečnokislinske bakterije, bifidobakterije, agroživilska veriga, odpornost, genetika

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Program financ.:Young researchers
Številka projekta:6316-1/2017-273

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Program financ.:Young researchers
Številka projekta:603-1/2017-13

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J4-1769
Naslov:Rezistomi probiotičnih in starterskih kultur kot potencialni dejavnik tveganja za širjenje odpornosti proti antibiotikom

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P4-0097
Naslov:Prehrana in mikrobna ekologija prebavil

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