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The role of endothelin B receptor in bone modelling during orthodontic tooth movement : a study on ET B knockout rats
ID
Disha Ibrahimi, Saranda
(
Avtor
),
ID
Furlani, Borut
(
Avtor
),
ID
Drevenšek, Gorazd
(
Avtor
),
ID
Plut, Alja
(
Avtor
),
ID
Yanagisawa, M
(
Avtor
),
ID
Hudoklin, Samo
(
Avtor
),
ID
Prodan Žitnik, Irena
(
Avtor
),
ID
Marc, Janja
(
Avtor
),
ID
Drevenšek, Martina
(
Avtor
)
PDF - Predstavitvena datoteka,
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(1,55 MB)
MD5: 6DEE2AE0DCF304FD9AA3B84C29FB1D4B
URL - Izvorni URL, za dostop obiščite
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450079/pdf/41598_2020_Article_71159.pdf
Galerija slik
Izvleček
The endothelin system has an important role in bone modelling during orthodontic tooth movement (OTM); however, little is known about the involvement of endothelin B receptors (ETB) in this process. The aim of this study was to evaluate the role of ETB in bone modelling during OTM using ETB knockout rats (ETB-KO). Thirty-two male rats were divided into 4 groups (n = 8 per group): the ETB-KO appliance group, ETB-KO control group, wild type (ETB-WT) appliance group, and ETB-WT control group. The appliance consisted of a super-elastic closed-coil spring placed between the first and second left maxillary molar and the incisors. Tooth movement was measured on days 0 and 35, and maxillary alveolar bone volume, osteoblast, and osteoclast volume were determined histomorphometrically on day 35 of OTM. Next, we determined the serum endothelin 1 (ET-1) level and gene expression levels of the osteoclast activity marker cathepsin K and osteoblast activity markers osteocalcin and dentin matrix acidic phosphoprotein 1 (DMP1) on day 35. The ETB-KO appliance group showed significantly lower osteoblast activity, diminished alveolar bone volume and less OTM than the ETB-WT appliance group. Our results showed that ETB is involved in bone modelling in the late stage of OTM.
Jezik:
Angleški jezik
Ključne besede:
orthodontic tooth movement
,
endothelin system
,
bone modelling
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FFA - Fakulteta za farmacijo
MF - Medicinska fakulteta
Različica publikacije:
Objavljena publikacija
Datum objave:
01.01.2020
Leto izida:
2020
Št. strani:
11 str.
Številčenje:
art. 14226, Vol. 10
PID:
20.500.12556/RUL-141299
UDK:
616.31
ISSN pri članku:
2045-2322
DOI:
10.1038/s41598-020-71159-8
COBISS.SI-ID:
27363587
Datum objave v RUL:
28.09.2022
Število ogledov:
473
Število prenosov:
68
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Objavi na:
Gradivo je del revije
Naslov:
Scientific reports
Skrajšan naslov:
Sci. rep.
Založnik:
Nature Publishing Group
ISSN:
2045-2322
COBISS.SI-ID:
18727432
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
ortodontsko gibanje zob
,
endotelinski sistem
,
modeliranje kosti
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0293-2020
Naslov:
Parodontalna medicina
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