20.500.12556/RUL-141299 The role of endothelin B receptor in bone modelling during orthodontic tooth movement a study on ET B knockout rats The endothelin system has an important role in bone modelling during orthodontic tooth movement (OTM); however, little is known about the involvement of endothelin B receptors (ETB) in this process. The aim of this study was to evaluate the role of ETB in bone modelling during OTM using ETB knockout rats (ETB-KO). Thirty-two male rats were divided into 4 groups (n = 8 per group): the ETB-KO appliance group, ETB-KO control group, wild type (ETB-WT) appliance group, and ETB-WT control group. The appliance consisted of a super-elastic closed-coil spring placed between the first and second left maxillary molar and the incisors. Tooth movement was measured on days 0 and 35, and maxillary alveolar bone volume, osteoblast, and osteoclast volume were determined histomorphometrically on day 35 of OTM. Next, we determined the serum endothelin 1 (ET-1) level and gene expression levels of the osteoclast activity marker cathepsin K and osteoblast activity markers osteocalcin and dentin matrix acidic phosphoprotein 1 (DMP1) on day 35. The ETB-KO appliance group showed significantly lower osteoblast activity, diminished alveolar bone volume and less OTM than the ETB-WT appliance group. Our results showed that ETB is involved in bone modelling in the late stage of OTM. orthodontic tooth movement endothelin system bone modelling ortodontsko gibanje zob endotelinski sistem modeliranje kosti true false false Angleški jezik Slovenski jezik Članek v reviji 2022-09-28 08:37:19 2022-09-28 08:37:24 2022-09-29 04:03:40 0000-00-00 00:00:00 2020 0 0 11 str. Vol. 10 art. 14226 2020 0000-00-00 Zaloznikova NiDoloceno NiDoloceno 0000-00-00 0000-00-00 2020-01-01 616.31 2045-2322 10.1038/s41598-020-71159-8 27363587 s41598-020-71159-8_(1).pdf s41598-020-71159-8_(1).pdf 1 6DEE2AE0DCF304FD9AA3B84C29FB1D4B 286827535f5547273b129a26aab9d85ed5611b48f78dbc87a2e8429f737fce06 43c8f50d-3ef8-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=162294 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450079/pdf/41598_2020_Article_71159.pdf 1 04ff99d0-3ef8-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=162293 Fakulteta za farmacijo Medicinska fakulteta 0 0 0