Trace elements and APOE polymorphisms in pregnant women and their new-borns

Trdin, Ajda (avtor), Snoj Tratnik, Janja (avtor), Stajnko, Anja (avtor), Marc, Janja (avtor), Mazej, Darja (avtor), Sešek-Briški, Alenka (avtor), Kastelec, Damijana (avtor), Prpić, Igor (avtor), Petrović, Oleg (avtor), Špirić, Igor (avtor), Horvat, Milena (avtor), Falnoga, Ingrid (avtor)

We investigated the relationship between lipid binding glycoprotein apolipoprotein E (apoE; gene APOE) polymorphisms (%4 allele carriers versus no carriers = 4+/4%) and trace elements (TEs) (e.g., (methyl)mercury, arsenic, lead, cadmium, selenium, manganese, copper, and zinc) in mothers (N = 223) and their new-borns (N = 213) exposed to potentially toxic metal(loid)s from seafood consumption. The apoE isoform encoded by the %4 allele is believed to have beneficial effects in early life but represents a risk factor for age-associated diseases. Under certain conditions %4 carriers are more susceptible to oxidative stress and metal(loid) toxicity. DNA from Croatian pregnant women (N = 223, third trimester) and their new-borns (N = 176), was genotyped for APOE by TaqMan% SNP assay % rs429358 and rs7412. Seafood intake data and TE levels in maternal urine, milk, hair, peripheral venous blood, mixed cord blood, and new-borns% urine were available from previous studies. We compared TEs between %4+ and %4% carriers using Mann-Whitney U tests and applied multiple linear regression models to analyse the TE%s dependence on the presence of allele %4 (genotypes 3/4,4/4) in combination with other explanatory variables. We identified 17% (n = 37) and 20% (n = 35) %4 allele carriers in mothers and new-borns, respectively. The Mann-Whitney U test showed that mothers with the %4 allele had significantly higher mean levels of (methyl)mercury in peripheral venous blood, cord blood, and hair; arsenic in urine and cord blood; and selenium in peripheral venous blood and plasma. However, taking confounders into account, only the maternal plasma selenium remained statistically significant in the linear regression models (%4 carriers vs non-carriers: 62.6 vs 54.9 ng/mL, p < 0.001). Literature suggestions of possible %4 allele impact on Hg levels were not observed, while superior selenium status observed in healthy pregnant women carrying allele %4 could be linked to the proposed APOE %4 beneficial effects early in life

• Jezik: Angleški jezik
• Ključne besede: ε4 allele, pregnancy, selenium, mercury, trace elements, apolipoprotein E polymorphism
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo ; BF - Biotehniška fakulteta
• Različica publikacije: Objavljena publikacija
• Datum objave: 01.01.2020
• Leto izida: 2020
• Št. strani: Str. 105626-1-105626-13
• Številčenje: Vol. 143, art. 105626
• PID: 20.500.12556/RUL-141284
• UDK: 543
• ISSN pri članku: 0160-4120
• DOI: 10.1016/j.envint.2020.105626
• COBISS.SI-ID: 24060675
• Datum objave v RUL: 28.09.2022

Gradivo je del revije

• Naslov: Environment international
• Skrajšan naslov: Environ. int.
• Založnik: Elsevier
• ISSN: 0160-4120
• COBISS.SI-ID: 25403136

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: kemija okolja

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: J7-9400-2018
• Naslov: Nevropsihološke disfunkcije, ki jih povzroča nizka stopnja izpostavljenosti izbranim onesnaževalom iz okolja pri občutljivi populaciji - NEURODYS

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0143-2020
• Naslov: Kroženje snovi v okolju, snovna bilanca in modeliranje okoljskih procesov ter ocena tveganja