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Trace elements and APOE polymorphisms in pregnant women and their new-borns
ID Trdin, Ajda (Avtor), ID Snoj Tratnik, Janja (Avtor), ID Stajnko, Anja (Avtor), ID Marc, Janja (Avtor), ID Mazej, Darja (Avtor), ID Sešek-Briški, Alenka (Avtor), ID Kastelec, Damijana (Avtor), ID Prpić, Igor (Avtor), ID Petrović, Oleg (Avtor), ID Špirić, Igor (Avtor), ID Horvat, Milena (Avtor), ID Falnoga, Ingrid (Avtor)

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Izvleček
We investigated the relationship between lipid binding glycoprotein apolipoprotein E (apoE; gene APOE) polymorphisms (%4 allele carriers versus no carriers = 4+/4%) and trace elements (TEs) (e.g., (methyl)mercury, arsenic, lead, cadmium, selenium, manganese, copper, and zinc) in mothers (N = 223) and their new-borns (N = 213) exposed to potentially toxic metal(loid)s from seafood consumption. The apoE isoform encoded by the %4 allele is believed to have beneficial effects in early life but represents a risk factor for age-associated diseases. Under certain conditions %4 carriers are more susceptible to oxidative stress and metal(loid) toxicity. DNA from Croatian pregnant women (N = 223, third trimester) and their new-borns (N = 176), was genotyped for APOE by TaqMan% SNP assay % rs429358 and rs7412. Seafood intake data and TE levels in maternal urine, milk, hair, peripheral venous blood, mixed cord blood, and new-borns% urine were available from previous studies. We compared TEs between %4+ and %4% carriers using Mann-Whitney U tests and applied multiple linear regression models to analyse the TE%s dependence on the presence of allele %4 (genotypes 3/4,4/4) in combination with other explanatory variables. We identified 17% (n = 37) and 20% (n = 35) %4 allele carriers in mothers and new-borns, respectively. The Mann-Whitney U test showed that mothers with the %4 allele had significantly higher mean levels of (methyl)mercury in peripheral venous blood, cord blood, and hair; arsenic in urine and cord blood; and selenium in peripheral venous blood and plasma. However, taking confounders into account, only the maternal plasma selenium remained statistically significant in the linear regression models (%4 carriers vs non-carriers: 62.6 vs 54.9 ng/mL, p < 0.001). Literature suggestions of possible %4 allele impact on Hg levels were not observed, while superior selenium status observed in healthy pregnant women carrying allele %4 could be linked to the proposed APOE %4 beneficial effects early in life

Jezik:Angleški jezik
Ključne besede:ε4 allele, pregnancy, selenium, mercury, trace elements, apolipoprotein E polymorphism
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
BF - Biotehniška fakulteta
Različica publikacije:Objavljena publikacija
Datum objave:01.01.2020
Leto izida:2020
Št. strani:Str. 105626-1-105626-13
Številčenje:Vol. 143, art. 105626
PID:20.500.12556/RUL-141284 Povezava se odpre v novem oknu
UDK:543
ISSN pri članku:0160-4120
DOI:10.1016/j.envint.2020.105626 Povezava se odpre v novem oknu
COBISS.SI-ID:24060675 Povezava se odpre v novem oknu
Datum objave v RUL:28.09.2022
Število ogledov:319
Število prenosov:71
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Environment international
Skrajšan naslov:Environ. int.
Založnik:Elsevier
ISSN:0160-4120
COBISS.SI-ID:25403136 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:kemija okolja

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J7-9400-2018
Naslov:Nevropsihološke disfunkcije, ki jih povzroča nizka stopnja izpostavljenosti izbranim onesnaževalom iz okolja pri občutljivi populaciji - NEURODYS

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P1-0143-2020
Naslov:Kroženje snovi v okolju, snovna bilanca in modeliranje okoljskih procesov ter ocena tveganja

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